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P2918

Sigma-Aldrich

Human Serum

from platelet poor human plasma, sterile-filtered, (mycoplasma tested, virus tested)

Synonym(s):
human plasma, human sera, human serum
MDL number:
NACRES:
NA.71

biological source

human

sterility

sterile-filtered

origin

USA origin

technique(s)

cell culture | mammalian: suitable

impurities

(mycoplasma tested, virus tested)
≤10 EU/mL endotoxin

shipped in

dry ice

storage temp.

−20°C

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This Item
H5667H4522H3667
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P2918

Human Serum

Human Serum Heat Inactivated (from male AB clotted whole blood), USA origin, sterile-filtered

Sigma-Aldrich

H5667

Human Serum

Human Serum from human male AB plasma, USA origin, sterile-filtered

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H4522

Human Serum

Human Serum Heat Inactivated, from human male AB plasma, USA origin, sterile-filtered

Sigma-Aldrich

H3667

Human Serum

sterility

sterile-filtered

sterility

sterile-filtered

sterility

sterile-filtered

sterility

sterile-filtered

origin

USA origin

origin

USA origin

origin

USA origin

origin

USA origin

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable, cell culture | stem cell: suitable

technique(s)

cell culture | mammalian: suitable, cell culture | stem cell: suitable

technique(s)

cell culture | mammalian: suitable

impurities

(mycoplasma tested, virus tested), ≤10 EU/mL endotoxin

impurities

≤10 EU/mL Endotoxin

impurities

≤10 EU/mL endotoxin

impurities

≤10 EU/mL endotoxin

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

The serum is the fluid part of the blood containing plasma without fibrinogen.

Application

Human Serum has been used:
  • in the preparation of human serum samples that mimic the COVID-19 patient samples for serological antibody testing
  • as a media supplement to differentiate human induced pluripotent stem cells (hiPS) to hiPS- brain microvascular endothelial cells (BMEC)
  • for culturing transgenic Plasmodium falciparum clone
  • for assessing the electrochemical response of recombinant P. falciparum parasite L-lactate dehydrogenase (LDH) in serum samples
  • in platelet-derived growth factor (PDGF) purification assays

Human serum from platelet poor plasma (PPP) is useful for studies of the effects of platelet lysates on the growth of cells such as articular chondrocytes and human skin fibroblasts. It has also been used in platelet derived growth factor (PDGF) purification assays.

Biochem/physiol Actions

Serum serves as a supplement to basal media formulations and conventional biomedical cell culture media. It acts as a source of trace nutrients, signaling molecules, growth factors, and hormones that induce proper cell growth in vitro. Human serum from platelet-poor plasma (PPP) is useful in the studies of the effects of platelet lysates on the growth of cells such as articular chondrocytes and human skin fibroblasts.

Analysis Note

Endotoxin tested

Other Notes

It is not unusual for a white precipitate to form following a freeze-thaw cycle for this human serum product.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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25G
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705578-5MG-PW

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MMYOMAG-74K-13

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Edward N O'Neill et al.
Comprehensive reviews in food science and food safety, 20(1), 686-709 (2020-12-17)
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Physiology, Blood Plasma null
Aver Hemben et al.
Talanta, 187, 321-329 (2018-06-02)
This paper describes the development of an affinity sensor for the detection of Plasmodium falciparum parasite lactate dehydrogenase (pLDH) as one of the biomarkers used for malaria detection. The gold sensor was functionalised with anti-pLDH after cleaning the electrode surface
Y C Choi et al.
Arthritis and rheumatism, 23(2), 220-224 (1980-02-01)
Human platelet lysate (PL) has a strong growth promoting action on rabbit articular chondrocytes in monolayer culture. The responsible factor is heat stable (56 degrees C, 30 minutes) and above 10,000 MW. PL (80 microgram protein/ml) reduces cell protein content
Marie Piantino et al.
Materials today. Bio, 14, 100232-100232 (2022-03-22)
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