Skip to Content
MilliporeSigma
All Photos(1)

Documents

P7556

Sigma-Aldrich

Progesterone-Water Soluble

powder, BioReagent, suitable for cell culture

Synonym(s):

Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex

Sign Into View Organizational & Contract Pricing


About This Item

MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

product line

BioReagent

form

powder

concentration

≥65% (HPLC)

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 25 mg/mL, clear to slightly hazy

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Progesterone is a steroid hormone secreted by the ovaries.

Application

Progesterone-Water Soluble has been used:
  • for in vitro maturation of oocyte complexes
  • as a σ1R antagonist to study its effect on sigma 1 receptor
  • to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro

This product is not recommended for use in binding assays.

Biochem/physiol Actions

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Packaging

Package size based on progesterone content

Other Notes

Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.

related product

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Neurosteroid Hormones Modulate the Differentiation of Adult Human Multipotent Mesenchymal Stromal Cells
Tiftikcioglu BI, et al.
Journal of stem cell research & therapy, 4(9), 2-2 (2012)
Adding hormones sequentially could be an effective approach for IVM of dog oocytes
Evecen M, et al.
Theriogenology, 75(9), 1647-1651 (2011)
Clinical Reproductive Medicine and Surgery, 838, 17-17 (2007)
Ligands exert Biased Activity to regulate Sigma 1 Receptor interactions with cationic TRPA1, TRPV1 and TRPM8 channels
Cortes ME, et al.
Frontiers in Pharmacology, 10(9), 634-634 (2019)
Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to uterine dysfunction
Dhakal P, et al.
Endocrinology, 156(10), 3791-3803 (2015)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service