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Key Documents

P9764

Sigma-Aldrich

Polydeoxyadenylic acid • Polythymidylic acid sodium salt

double-stranded homopolymer

Synonym(s):

Poly(dA) • Poly(dT)

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About This Item

CAS Number:
86834-22-2
MDL number:
MFCD00131963
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

form

powder

storage temp.

−20°C

InChI

1S/C10H14N5O6P.C10H15N2O8P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19;1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19);3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)

InChI key

KKVQVIFXABFJCS-UHFFFAOYSA-N

Application

Polydeoxyadenylic acid • Polythymidylic acid (Poly(dA) • Poly(dT)) is a double-stranded homopolymer use as a DNA model for conformational studies of DNA structure dynamics and drug interaction.

Other Notes

Double-stranded homopolymer

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B Gong et al.
Biochemical and biophysical research communications, 240(3), 557-560 (1997-12-17)
New DNA minor-groove binding molecules with high binding affinities and sequence-selectivities are described. The effects of structural changes in ligands with a three-ring backbone on their DNA-binding properties have been studied. Of a pool of eight potential ligands, two showed
R Cao et al.
Journal of biomolecular structure & dynamics, 18(6), 844-856 (2001-07-11)
The DNA binding behavior of a tricationic cyanine dye (DiSC3+(5)) was studied using the [Poly(dA-dT)]2, [Poly(dI-dC)]2 and Poly(dA) x Poly(dT) duplex sequences and the Poly(dA) x 2Poly(dT) triplex. Optical spectroscopy and viscometry results indicate that the dye binds to the
U Sehlstedt et al.
Journal of molecular biology, 278(1), 31-56 (1998-05-26)
The binding of an antiviral quinoxaline derivative, 2,3-dimethyl- 6 - (dimethylaminoethyl) - 9 - hydroxy - 6H - indolo - [2,3 - b]quinoxaline (9-OH-B220), to synthetic double and triple helical DNA (poly(dA).poly(dT) and poly(dA).2poly(dT)) and RNA (poly(rA). poly(rU) and poly
K M Kosikov et al.
Journal of molecular biology, 289(5), 1301-1326 (1999-06-22)
Computer-simulated elongation and compression of A - and B -DNA structures beyond the range of thermal fluctuations provide new insights into high energy "activated" forms of DNA implicated in biochemical processes, such as recombination and transcription. All-atom potential energy studies
T Ha Duong et al.
Journal of biomolecular structure & dynamics, 14(6), 691-701 (1997-06-01)
DNA-drug complexes are important because of their pharmacological interest but, in addition, they provide a useful model to study the essential aspects of DNA recognition processes. In order to investigate the influence of ligand binding on the dynamic properties of
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