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P9767

Sigma-Aldrich

Sodium palmitate

≥98.5%

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Synonym(s):
Hexadecanoic acid sodium salt, Palmitic acid sodium salt
Linear Formula:
CH3(CH2)14COONa
CAS Number:
Molecular Weight:
278.41
Beilstein:
3575882
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

biological source

plant (palm)

Quality Level

Assay

≥98.5%

form

powder

mp

283-290 °C (lit.)

functional group

ester

lipid type

saturated FAs

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].CCCCCCCCCCCCCCCC([O-])=O

InChI

1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1

InChI key

GGXKEBACDBNFAF-UHFFFAOYSA-M

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1 of 4

This Item
S3381C4151O7501
Sodium palmitate ≥98.5%

Sigma-Aldrich

P9767

Sodium palmitate

Sodium stearate ≥99%

Sigma-Aldrich

S3381

Sodium stearate

Sodium decanoate ≥98%

Sigma-Aldrich

C4151

Sodium decanoate

Sodium oleate ≥99%

Sigma-Aldrich

O7501

Sodium oleate

assay

≥98.5%

assay

≥99%

assay

≥98%

assay

≥99%

form

powder

form

powder

form

powder

form

powder

mp

283-290 °C (lit.)

mp

-

mp

-

mp

232-235 °C (lit.)

functional group

ester

functional group

ester

functional group

ester

functional group

ester

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

Application

Sodium palmitate (PA) has been used:
  • to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
  • to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
  • as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

Biochem/physiol Actions

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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José M S Fernández-Calleja et al.
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Indirect calorimetry (InCa) estimates whole-body energy expenditure and total substrate oxidation based on O2 consumption and CO2 production, but does not allow for the quantification of oxidation of exogenous substrates with time. To achieve this, we incorporated 13CO2 and 12CO2
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Articles

Information on fatty acid synthesis and metabolism in cancer cells. Learn how proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sources or are synthesized by the cell.

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