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PLA0181

Sigma-Aldrich

Rabbit anti-PSF/SFPQ Antibody, Affinity Purified

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Synonym(s):
100 kDa DNA-pairing protein, 100 kDa subunit, DNA-binding p52/p100 complex, POMP100, PPP1R140, PSF, PTB-associated splicing factor, PTB-associated-splicing factor, hPOMp100, polypyrimidine tract binding protein associated, polypyrimidine tract-binding protein-associated splicing factor, polypyrimidine tract-binding protein-associated-splicing factor, protein phosphatase 1, regulatory subunit 140, splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated), splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated), splicing factor proline/glutamine-rich
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

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species reactivity

human, mouse

technique(s)

immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_005057.1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... PSF/SFPQ(6421)

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This Item
P2860PLA0108HPA047420
species reactivity

human, mouse

species reactivity

mouse, human

species reactivity

human, mouse

species reactivity

human

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

Gene Information

rabbit ... PSF/SFPQ(6421)

Gene Information

human ... TAP1(6890)

Gene Information

rabbit ... DDB1(1642)

Gene Information

human ... PTBP2(58155)

technique(s)

immunohistochemistry: 1:100- 1:500, western blot: 1:2,000- 1:10,000, immunoprecipitation (IP): 2-5 μg/mg

technique(s)

immunocytochemistry: suitable, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, microarray: suitable, radioimmunoassay: suitable using cells, western blot: 2-4 μg/mL using whole extract of cultured HeLa cells

technique(s)

immunohistochemistry: 1:500- 1:2,000, immunoprecipitation (IP): 2-5 μg/mg, western blot: 1:1,000- 1:10,000

technique(s)

immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:200-1:500

shipped in

wet ice

shipped in

-

shipped in

wet ice

shipped in

wet ice

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Immunogen

The epitope recognized by PLA0181 maps to a region between residue 225 and 275 of human Polypyrimidine tract-binding protein-associated-splicing factor (Splicing factor, proline- and glutamine-rich) using the numbering given in entry NP_005057.1 (GeneID 6421).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

PSF/SFPQ is a multifunctional protein know to participate in a variety of nuclear processes and may function to link transcription and pre-mRNA processing. PSF/SFPQ bears an RNA recognition motif (RRM) further indicating its role in post-transcriptional processes. PSF has been shown to associate with p54nrb/NonO to modulate androgen receptor-mediated transcription. Additionally, it has recently been show to associate with XRN2 and p54nrb/NonO to facilitate pre-mRNA 3′ processing and transcription termination.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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