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PRS4379

Sigma-Aldrich

Anti-Nhe-1 (ab2) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Na+/H+ antiporter, Anti-SLC9A1, Anti-Sodium-hydrogen exchanger 1, Anti-Solute carrier family 9 (sodium/hydrogen exchanger), member 1, Anti-Solute carrier family 9 member 1

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50 G
$273.00
100 G
$401.00
500 G
$1,230.00
1 KG
$2,110.00
5 KG
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$273.00


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50 G
$273.00
100 G
$401.00
500 G
$1,230.00
1 KG
$2,110.00
5 KG
Inquire
10 KG
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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

$273.00


In StockDetails


biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

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This Item
A9647A8022A9430
assay

≥98%

assay

≥98%

assay

≥96%

assay

≥98%

origin

USA origin

origin

USA origin

origin

USA origin

origin

USA origin

technique(s)

blood typing: suitable, microbiological culture: suitable

technique(s)

immunocytochemistry: suitable

technique(s)

ELISA: suitable, blocking: suitable, electrophoresis: suitable, western blot: suitable

technique(s)

ELISA: suitable, microbiological culture: suitable

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

General description

SLC9A1 (solute carrier family 9 member A1)/Na+/H+ exchanger 1 (NHE1), a plasma membrane transporter, is mapped to human chromosome 1p36. It belongs to the NHE family. NHE1 is abundantly expressed in all organisms.

Immunogen

a 17 amino acid peptide near the center of the human Nhe-1.

Application

Anti-Nhe-1 (ab2) antibody has been used in immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

Na+/H+ exchanger 1 (NHE1) modulates intracellular pH by exchanging a proton for an extracellular sodium ion and affects cell growth, proliferation, migration and apoptosis. It plays a major role in cancers including breast cancer, hepatocellular carcinoma, colon cancer, pancreatic ductal adenocarcinoma, prostate cancer, cervical cancer and neuroblastoma.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4379.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma.
Ariyoshi Y, et al.
Oncotarget, 8(2), 2209-2209 (2017)
Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis.
Zhao FR, et al.
Experimental and Therapeutic Medicine, 10(5), 1627-1634 (2015)
D S Lim et al.
Journal of the American College of Cardiology, 38(4), 1175-1180 (2001-10-05)
The goal of this study was to identify genes upregulated in the heart in human patients with hypertrophic cardiomyopathy (HCM). Hypertrophic cardiomyopathy is a genetic disease caused by mutations in contractile sarcomeric proteins. The molecular basis of diverse clinical and
Fan-Rong Zhao et al.
Experimental and therapeutic medicine, 10(5), 1627-1634 (2015-12-08)
The aim of this study was to investigate the protective effects of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rabbits and to explore the underlying mechanisms in order to provide experimental evidence for the clinical application of XMJ. An

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