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R4632

Sigma-Aldrich

Retinyl acetate

synthetic, crystalline solid or supercooled liquid

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Synonym(s):
Retinol acetate, Vitamin A acetate
Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
Molecular Weight:
328.49
Beilstein/REAXYS Number:
1915439
EC Number:
MDL number:
eCl@ss:
34058009
PubChem Substance ID:
NACRES:
NA.79

biological source

synthetic

assay

≥90% (HPLC)

form

crystalline solid or supercooled liquid

potency

2,600,000-2,940,000 I.U. per g

color

light yellow to dark yellow

mp

57-58 °C
~58 °C (lit.)

storage temp.

−20°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

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This Item
R3250R0635R7882
vibrant-m

R4632

Retinyl acetate

vibrant-m

R3250

Retinyl acetate

vibrant-m

R0635

Retinyl Acetate-Water Soluble

vibrant-m

R7882

Retinyl acetate

biological source

synthetic

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

form

crystalline solid or supercooled liquid

form

matrix dispersion

form

powder

form

solid or viscous liquid

mp

57-58 °C, ~58 °C (lit.)

mp

57-58 °C

mp

57-58 °C

mp

57-58 °C

color

light yellow to dark yellow

color

yellow

color

white to light yellow

color

light yellow to dark yellow

General description

Vitamin A usually occurs in food as retinyl esters, which are the pre-formed sources of vitamin A. Retinyl acetate exists as yellow crystals and is insoluble in water. It is soluble in ethanol and oils.

Application

Retinyl acetate has been used:
  • to study its effects on cochlear development in mice
  • as a component of an internal standard to quantify antioxidants in yolk
  • as an internal standard to determine serum retinol concentration

Biochem/physiol Actions

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinyl acetate is used in a wide range of biological applications.

Physical form

Packaged as a melt and may exist as a crystalline solid or a supercooled viscous liquid

Analysis Note

Activity based on HPLC comparison to USP standard.

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Retinol ≥95.0% (HPLC), ~2700 U/mg

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Cholecalciferol

The common marmoset in captivity and biomedical research
Marini RP
Common Fragrance and Flavor Materials (2018)
Capillary electrophoresis Food Additives
Frazier RA
Encyclopedia of Separation Science (2007)
Buhler Volker
Vademecum for Vitamin Formulations (2001)
Effects of retinoid treatment on cochlear development, connexin expression and hearing thresholds in mice
Kim Yy, et al.
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-rhino-laryngologie et de Chirurgie Cervico-Faciale (2018)
Assessment of the relative dose-response test based on serum retinol-binding protein instead of serum retinol in determining low hepatic vitamin A stores
Fujita M, et al.
American Journal of Clinical Nutrition (2009)

Protocols

Following GB method for Vitamin A and Vitamin E as it is written with a 250 x 4.6 mm Ascentis® Express C30 column gives baseline resolution between the critical pair (gamma-, and beta-tocopherol; peaks 3 and 4).

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