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S1764

Sigma-Aldrich

Complement sera human

lyophilized powder

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MDL number:
MFCD00130855
NACRES:
NA.61

biological source

human

Quality Level

200

form

lyophilized powder

origin

USA origin

technique(s)

cell culture | mammalian: suitable

impurities

virus, tested

shipped in

dry ice

storage temp.

−20°C

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S1764

Complement sera human

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S7023

Sera human

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S2257

Sera human

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204882

Complement C2, Human

form

lyophilized powder

form

frozen liquid

form

lyophilized powder (from clotted whole blood)

form

liquid

origin

USA origin

origin

USA origin

origin

USA origin

origin

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

impurities

virus, tested

impurities

-

impurities

-

impurities

C1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin, trace

shipped in

dry ice

shipped in

dry ice

shipped in

-

shipped in

wet ice

General description

Complement serum is prepared from pooled human plasma and lyophilized from the amount of serum indicated on the label.

Application

Complement sera human has been used:
  • to incubate DLD-1 or SW-620 cells to quantify C5a release
  • in multiplex bead antibody-binding assay to assay C3d
  • in complement-dependent cytotoxicity assay

Complement sera human has been used:
  • to incubate DLD-1 or SW-620 cells to quantify C5a release
  • in multiplex bead antibody-binding assay to assay C3d
  • in complement-dependent cytotoxicity assay

The activity of complement sera can be determined by hemolytic assays in vitro.

Physical form

Lyophilized powder from indicated amount of serum

Analysis Note

Hemolytic titer (CH50 units per ml) is determined by method of Kabat and Mayer. Actual titer given on label.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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The programmed cell death protein 1 receptor (PD-1) and programmed death ligand 1 (PD-L1) coinhibitory pathway suppresses T-cell-mediated immunity. We hypothesized that cotargeting of PD-1 and PD-L1 with a bispecific antibody molecule could provide an alternative therapeutic approach, with enhanced
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Clinical cancer research : an official journal of the American Association for Cancer Research, 25(14), 4388-4399 (2019-04-26)
The anti-CCR4 mAb, mogamulizumab, offers therapeutic benefit to patients with adult T-cell leukemia-lymphoma (ATL), but skin-related adverse events (AE) such as erythema multiforme occur frequently. The purpose of this study was to determine the mechanisms by which mogamulizumab causes skin-related
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Baculovirus vectors (BVs) are safely able to transduce foreign genes and express them in mammalian cells. However, the transduction activity of BVs is strongly reduced by the attack of serum complement, which is one of the major obstacles in the
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Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role in the development of vaccines and antibody-based interventions. We report systemic and mucosal antibody responses in convalescent individuals who experienced varying disease severity. Robust antibody responses to diverse
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