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S9761

Sigma-Aldrich

N-Succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin

Leucine aminopeptidase substrate

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Empirical Formula (Hill Notation):
C34H39N5O9
CAS Number:
Molecular Weight:
661.70
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥98% (HPLC)

form

powder

solubility

methanol: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(NC(=O)CCC(O)=O)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(Cc2ccccc2)C(=O)Nc3ccc4C(C)=CC(=O)Oc4c3

InChI

1S/C34H39N5O9/c1-19-16-30(43)48-27-18-23(11-12-24(19)27)37-32(45)25(17-22-8-5-4-6-9-22)38-33(46)26-10-7-15-39(26)34(47)21(3)36-31(44)20(2)35-28(40)13-14-29(41)42/h4-6,8-9,11-12,16,18,20-21,25-26H,7,10,13-15,17H2,1-3H3,(H,35,40)(H,36,44)(H,37,45)(H,38,46)(H,41,42)

InChI key

FMVUZZZUYBXQGR-UHFFFAOYSA-N

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This Item
S8758A8171B4636
solubility

methanol: 50 mg/mL, clear, colorless

solubility

50% acetic acid: 1 mg/mL, clear, colorless

solubility

water: 1 mg/mL, clear, colorless

solubility

ethanol: 2 mg/mL, clear, colorless

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Activity of cathepsin H,B and metalloproteinase in the serum of patients with acute myocardial infarction.
A László et al.
Clinica chimica acta; international journal of clinical chemistry, 210(3), 233-235 (1992-09-30)
Julián Gamboa-Delgado et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 158(4), 251-258 (2010-12-21)
The effect of diet on larval growth, anionic trypsinogen gene expression (ssetryp1), and trypsin (EC 3.4.21.4) and chymotrypsin (EC 3.4.21.1) activities was assessed in Solea senegalensis. Changes in larval carbon stable isotope (δ(13)C) composition were used to estimate carbon assimilation.
I Sohár et al.
Acta biologica Hungarica, 42(1-3), 265-274 (1991-01-01)
Previously, MMP-7ases were isolated from rat skeletal muscle by gel filtration and anion exchange chromatography. The enzyme that hydrolyzed succinyl-Ala-Ala-Pro-Phe-AMC (AMC: 7-amino-4-methyl-coumarin) was inhibited by EDTA. In this study we attempted to isolate MMP-7ase from mouse kidney. The isolation procedure
G B Irvine et al.
Analytical biochemistry, 185(2), 304-307 (1990-03-01)
A simple, inexpensive, and sensitive assay for peptidase activity has been devised. The assay was performed in a microtiter plate and was based on fluorogenic peptide substrates, many of which are commercially available. 7-Amino-4-methyl coumarin the fluorescent product liberated during
Brittany Butts et al.
Frontiers in cardiovascular medicine, 10, 1132786-1132786 (2023-06-02)
Chymase is a highly destructive serine protease rapidly neutralized in the circulation by protease inhibitors. Here we test whether pericardial fluid (PCF) chymase activation and other inflammatory biomarkers determine intensive care unit length of stay, and explore mechanisms of chymase

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