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B7260

Sigma-Aldrich

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride

protease substrate

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Synonym(s):
Bz-Arg-AMC hydrochloride
Empirical Formula (Hill Notation):
C23H25N5O4 · HCl
CAS Number:
Molecular Weight:
471.94
MDL number:
PubChem Substance ID:
NACRES:
NA.83

Quality Level

assay

≥99% (TLC)

form

powder

solubility

DMSO:methanol (1:1): 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)c3ccccc3)ccc12

InChI

1S/C23H25N5O4.ClH/c1-14-12-20(29)32-19-13-16(9-10-17(14)19)27-22(31)18(8-5-11-26-23(24)25)28-21(30)15-6-3-2-4-7-15;/h2-4,6-7,9-10,12-13,18H,5,8,11H2,1H3,(H,27,31)(H,28,30)(H4,24,25,26);1H/t18-;/m0./s1

InChI key

XKAVYOJOHZLTDF-FERBBOLQSA-N

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This Item
A2027C8022T0273
solubility

DMSO:methanol (1:1): 20 mg/mL, clear, colorless

solubility

acetic acid: water (1:1): 50 mg/mL, clear, colorless to light yellow

solubility

methanol: 20 mg/mL, clear, colorless to faintly yellow

solubility

acetic acid: 10 mg/mL, clear, colorless

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Application

Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride has been used:
  • as a substrate for trypsin-like proteolysis of peptide in red blood cells
  • as a substrate for midgut proteases of Pieris brassicae
  • as a substrate in screening serine protease activity of venom

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

A sensitive fluorogenic substrate for papain and trypsin.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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