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Key Documents

SAB2500481

Sigma-Aldrich

Anti-GPR40 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-G protein-coupled receptor 40, Anti-HGNC:4498

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: suitable

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GPR40(2864)

General description

G protein-coupled receptor 40 (GPR40) belongs to the G protein-coupled receptors. It is a 300 amino acid protein, that has seven characteristic transmembrane domains. GPR40 is also known as FFA1 (free fatty acid receptor 1). It is expressed in the β cell of the pancreas, spinal cord and brain. It is located on human chromosome 19q13.

Immunogen

Peptide with sequence CAARTQGGKSQK from the C Terminus of the protein sequence according to NP_005294.1.

Biochem/physiol Actions

G protein-coupled receptor 40 (GPR40) maintains insulin and glucose homeostasis. It plays an important role in the development of type 2 diabetes. GPR40/FFA1 signaling may participate in the regulation of endogenous pain control systems. It is considered as an anti-diabetic drug target.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A single amino acid mutation (R104P) in the E/DRY motif of GPR40 impairs receptor function
Guo Shimeng, et al.
PLoS ONE, 10(10), e0141303-e0141303 (2015)
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
Briscoe Celia P, et al.
The Journal of Biological Chemistry, 278(13), 11303-11311 (2003)
A New Pain Regulatory System via the Brain Long Chain Fatty Acid Receptor GPR40/FFA1 Signal.
Nakamoto, et al.
Yakugaku Zasshi, 137(2), 199-204 (2017)

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