SAB4300124

Anti-phospho-JAK2 (pTyr¹⁰⁰⁷) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-JTK10 antibody produced in rabbit, Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~125 kDa
• species reactivity: mouse, rat, human
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (K-E-YP-Y-K)
• NCBI accession no.: NP_004963.1
• UniProt accession no.: O60674
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr1007)
• Gene Information: human ... JAK2(3717)

Description

General description

Janus kinase 2(JAK2) mapped on human chromosome 9p24, encodes a tyrosine kinase. The encoded protein is a member of the Jak family of protein. JAK2 is ubiquitously expressed. This protein contains a catalytic domain and protein–protein interaction domain.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K), according to the protein JAK2.

Biochem/physiol Actions

Janus kinase 2(JAK2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy. In addition, mutations in the gene has also been observed in polycythaemia vera patients.

Features and Benefits

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Target description

Plays a role in leptin signaling and control of body weight.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable