SAB4501602

Anti-JAK2 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): JAK-2, JAK2, Janus kinase 2, kinase Jak2
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 130 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:5000; immunohistochemistry: 1:50-1:100
• NCBI accession no.: O60674
• UniProt accession no.: O60674
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... JAK2(3717)

Description

General description

Anti-JAK2 Antibody detects endogenous levels of total JAK2 protein.
JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the Jak family of proteins. The JAK2 gene is located on human chromosome 9p24.

Immunogen

The antiserum was produced against synthesized peptide derived from human JAK2.

Immunogen Range: 906-955

Biochem/physiol Actions

JAK2 (janus kinase 2) plays an important role in the activities of cytokine receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable