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SAB4300345

Sigma-Aldrich

Anti-ESR1 (Ab-106) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-DKFZp686N23123 antibody produced in rabbit, Anti-ER antibody produced in rabbit, Anti-ESR antibody produced in rabbit, Anti-ESRA antibody produced in rabbit, Anti-estrogen receptor 1 antibody produced in rabbit
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~66 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(S-P-S-P-L)

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ESR1(2099)

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This Item
HPA000449HPA000450SAB4300490
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

mol wt

~66 kDa

mol wt

-

mol wt

-

mol wt

~220 kDa

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General description

Estrogen receptor 1 (ESR1) encodes estrogen receptor α (ERα) protein, otherwise known as nuclear receptor subfamily 3, group A, member 1 (NR3A1), binds to estrogen. High expression of ERα is observed in tissues such as the epididymis, uterus, kidney and adrenal glands. In human chromosome, the gene ESR1 is localized on 6q25.1-q25.2.

Immunogen

Peptide sequence around aa. 104-108 (S-P- S-P-L), according to the protein ESR1.

Biochem/physiol Actions

Estrogen receptor 1 (ESR1) interacts with the nuclear transcription factor Sp1 in the presence of estradiol and regulates expression of diverse cellular and viral genes. ESR1 upon activation by estradiol interacts with transcription factor Sp3 and down regulates vascular endothelial growth factor (VEGF) in endometrial cancer cells. ESR1 tethers to DNA by protein-protein interaction with other transcription factor like activator protein 1 (AP1) family members like c-Jun, c-Fos and activating transcription factor (ATF). ESR1 and NF-κB cooperatively upregulates anti-apoptotic Baculoviral IAP (inhibitor of apoptosis protein) Repeat Containing 3 (BIRC3) and promotes breast cancer cell survival and tumor progression. Deleted in bladder cancer protein 1 (DBC1) modulates the expression of ESR1 and may promote the proliferation of breast cancer tissues. Interleukin-6 expression is suppressed by ligand activated ESR1 through interaction with NF-κB and thereby inhibits osteoporosis. ESR1 is potent in maintaining human immunodeficiency virus (HIV) latency and it is noted that latency maintenance and the amount of HIV RNA is gender specific, since women are more sensitive to estrogen.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway
Heldring N, et al.
Molecular Endocrinology, 25(4), 564-574 (2011)
Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements
Saville B, et al.
The Journal of Biological Chemistry, 275(8), 5379-5387 (2000)
CBP mediates NF-kappaB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter
Pradhan M, et al.
Molecular and Cellular Biology, 32(2), 569-575 (2012)
Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins
Stoner M, et al.
The Journal of Biological Chemistry, 275(30), 22769-22779 (2000)
Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
Das B, et al.
Proceedings of the National Academy of Sciences of the USA, 115(33), E7795-E7804 (2018)

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