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SAB4501488

Sigma-Aldrich

Anti-GPR109 antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, GPR109B, Nicotinic acid receptor 2
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HCAR3(8843)

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SAB4500868SAB4500633SAB4501351
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

mol wt

antigen 44 kDa

mol wt

antigen 59 kDa

mol wt

antigen 116 kDa

mol wt

antigen 36 kDa

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General description

Anti-GPR109 antibody detects endogenous levels of total GPR109 protein.
GPR109B (G-protein coupled receptor 109B) is also called as hydroxycarboxylic acid receptor 3 (HCA3) and HM74 (G-protein coupled receptor). It belongs to the subfamily of G-protein-coupled receptors (GPCR). GPR109B is expressed in adipose tissue, lung, spleen and peripheral blood leukocytes. It is mapped to human chromosome 12q24.31.

Immunogen

The antiserum was produced against synthesized peptide derived from human GPR109.

Immunogen Range: 285-334

Biochem/physiol Actions

GPR109B (G-protein coupled receptor 109B) helps to carry out the activities of D-Phe and D-Trp on neutrophils. HCA3 receptors helps to activate ERK1/2 through PTX (Pertussis toxin)-sensitive Gi (inhibitory G) protein-dependent pathway.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways
Zhou Q, et al.
British Journal of Pharmacology, 166(6), 1756-1773 (2012)
Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B
Irukayama-Tomobe Y, et al.
Proceedings of the National Academy of Sciences of the USA, 106(10), 3930-3934 (2009)
Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation
Bermudez Y, et al.
PLoS ONE (2011)

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