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SAB4502960

Sigma-Aldrich

Anti-TGF β Receptor II antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
TβR-II, TGF-β receptor type II, TGF-β type II receptor, TGFR-2, Transforming growth factor-β receptor type II
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 64 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TGFBR2(7048)

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antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

technique(s)

ELISA: 1:20000, western blot: 1:500-1:1000

technique(s)

immunofluorescence: 1:50-1:200, immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

technique(s)

ELISA: 1:5000, immunohistochemistry: 1:50-1:100

technique(s)

immunohistochemistry: 1:50-1:100, western blot: 1:1000

species reactivity

mouse, rat, human

species reactivity

rat, human, mouse

species reactivity

mouse, rat, human

species reactivity

human, mouse

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

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General description

Anti-TGF β Receptor II Antibody detects endogenous levels of total TGF β Receptor II protein.
Transforming growth factor β receptor 2 (TGFBR2) is a serine/threonine protein kinase, that belongs to the TGF β receptor subfamily. It is located on human chromosome 3p24.

Immunogen

The antiserum was produced against synthesized peptide derived from human TGF beta Receptor II.

Immunogen Range: 91-140

Application

Anti-TGF β Receptor II antibody has been used in immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

Transforming growth factor β receptor 2 (TGFBR2) plays an important role in signal transduction resulting in mitogenic responses. Mutation in TGFBR2 result in Loeys-Dietz syndrome and Marfan syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Heterozygous TGFBR2 mutations in Marfan syndrome.
Mizuguchi T, et al.
Nature Genetics, 36(8), 855?860-855?860 (2004)
TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells.
Fricke F, et al.
Cell communication and signaling : CCS, 15(1), 14-14 (2017)
Arthrogryposis as neonatal presentation of Loeys-Dietz syndrome due to a novel TGFBR2 mutation.
Valenzuela I, et al.
European Journal of Human Genetics, 60(6), 303-307 (2017)
A new candidate substrate for cell-matrix adhesion study: the acellular human amniotic matrix.
Guo Q, et al.
BioMed Research International, 2012, 10-10 (2012)
Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing
Zimmermann MT, et al.
PLoS ONE, 12(2), e0170822-e0170822 (2017)

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