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SAB4503021

Sigma-Aldrich

Anti-p53 antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Antigen NY-CO-13, Cellular tumor antigen p53, Phosphoprotein p53, TP53, tumor protein p53
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 43 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TP53(7157)

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This Item
SAB4503015SAB4503008SAB4503010
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

technique(s)

ELISA: 1:20000, immunohistochemistry: 1:50-1:100, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

technique(s)

ELISA: 1:10000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

technique(s)

ELISA: 1:10000, western blot: 1:500-1:1000

technique(s)

ELISA: 1:20000, western blot: 1:500-1:1000

mol wt

antigen 43 kDa

mol wt

antigen 43 kDa

mol wt

antigen 43 kDa

mol wt

antigen 43 kDa

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General description

Anti-p53 Antibody detects endogenous levels of total p53 protein.
TP53 gene is mapped to human chromosome 17p13.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human p53.

Immunogen Range: 344-393

Biochem/physiol Actions

TP53 gene is involved in the regulation of cell cycle, senescence and apoptosis upon oncogene activation, stress and DNA damage. Therefore, the gene has anti-tumor activity initiation and prevents tumor progression. Mutation in TP53 is known to be the major cause of almost half of all human malignancy. Breast cancer is one such condition in which, the disease development is severe due to mutation in TP53 gene.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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1000309185

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Monika Vishnoi et al.
Cancer research, 78(18), 5349-5362 (2018-07-22)
Systemic metastasis is the major cause of death from melanoma, the most lethal form of skin cancer. Although most patients with melanoma exhibit a substantial gap between onset of primary and metastatic tumors, signaling mechanisms implicated in the period of
Wip1 phosphatase: between p53 and MAPK kinases pathways
Goloudina, AR
Oncotarget, 7(21), 31563?31571-31563?31571 (2016)
TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting
Fountzilas
Oncotarget, 7(22), 32731?3275-32731?3275 (2016)
Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity
Sriraman A
Oncotarget, 7(22), 31623?31638-31623?31638 (2016)
Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy
Ridinger MS
PLoS ONE, 12(12), 1-22 (2017)

Articles

p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.

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