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SAB4700622

Sigma-Aldrich

Monoclonal Anti-Ly6g-FITC antibody produced in rat

clone RB6-8C5, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-Gr-1, Anti-Gr1, Anti-Ly-6G
NACRES:
NA.41

biological source

rat

Quality Level

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RB6-8C5, monoclonal

form

buffered aqueous solution

species reactivity

mouse

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG2b

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

mouse ... Ly6g(546644)

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This Item
SAB4700621MABF470MABF148A
Gene Information

mouse ... Ly6g(546644)

Gene Information

mouse ... Ly6g(546644)

Gene Information

mouse ... Ly6G(546644)

Gene Information

mouse ... Ly6G(546644)

conjugate

FITC conjugate

conjugate

unconjugated

conjugate

FITC conjugate

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

purified antibody

biological source

rat

biological source

rat

biological source

rat

biological source

rat

clone

RB6-8C5, monoclonal

clone

RB6-8C5, monoclonal

clone

1A8, monoclonal

clone

RB6-8C5, monoclonal

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General description

Lymphocyte antigen 6 complex, locus G (Ly6G) is a 25kDa glycosylphosphatidylinositol (GPI)–anchored protein. It is encoded by the gene mapped to mouse chromosome 15. The encoded protein belongs to the Ly6/urokinase plasminogen activator receptor (uPAR) family. Ly6G is characterized with a “3 finger fold” motif stabilized by 4-5 disulfide bonds. Ly6G is expressed only in mice.
The rat monoclonal antibody RB6-8C5 detects Ly6G component of Gr-1 antigen, a commonly used surface marker of neutrophils.

Immunogen

Murine granulocytes

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

The protein folds of lymphocyte antigen 6 complex, locus G (Ly6G) help to form a docking site for other molecules. Ly6G functions as a marker for neutrophils. The encoded protein might be implicated in the modulation of leukocyte migration.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Ly6G ligation blocks recruitment of neutrophils via a β2-integrin?dependent mechanism
Wang JX
Blood, 120, 1489-1498 (2012)
Ly6 family proteins in neutrophil biology
Lee PY
Journal of Leukocyte Biology, 94, 585-594 (2013)
Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo
Yipp BG and Kubes P
Blood, 121, 241-242 (2013)
Yangyang Zhang et al.
Diabetes, 69(7), 1549-1561 (2020-04-30)
Diabetic keratopathy, a sight-threatening corneal disease, comprises several symptomatic conditions including delayed epithelial wound healing, recurrent erosions, and sensory nerve (SN) neuropathy. We investigated the role of neuropeptides in mediating corneal wound healing, including epithelial wound closure and SN regeneration.

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