MilliporeSigma
All Photos(1)

Documents

SAB5500103

Sigma-Aldrich

Anti-F4/80 antibody, Rabbit monoclonal

clone SP115, recombinant, expressed in proprietary host, affinity isolated antibody

Sign Into View Organizational & Contract Pricing

NACRES:
NA.41

biological source

rabbit

Quality Level

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

SP115, monoclonal

species reactivity

mouse (tested)

species reactivity (predicted by homology)

rat

technique(s)

immunohistochemistry: 1:100

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... ADGRE1(2015)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SAB5500040SAB5500188MABF152C
recombinant

expressed in proprietary host

recombinant

expressed in proprietary host

recombinant

expressed in proprietary host

recombinant

-

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

clone

SP115, monoclonal

clone

SP192, monoclonal

clone

SP215, monoclonal

clone

BM8.1, monoclonal

species reactivity

mouse (tested)

species reactivity

human (tested)

species reactivity

human (tested)

species reactivity

mouse

Still not finding the right product?  

Give our Product Selector Tool a try.

General description

EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) is a human homolog of F4/80, an eosinophil-specific receptor. It is abundantly expressed on leukocytes. F4/80 is a member of the GPCR superfamily. It has N-terminal EGF (epidermal growth factor)-like domains bound to a seven-span transmembrane (7TM) moiety through a mucin-like spacer domain. This gene is located on human chromosome 19p13.
Mouse EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1) or cell surface glycoprotein F4/80 is a cell surface glycoprotein and a member of the EGF TM7 family of proteins. It shares 68% overall amino acid identity with human EGF-module-containing-mucin-like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ regulatory T cells.

Immunogen

Synthetic peptide derived from N-terminus of mouse F4/80 protein.

Application

Anti-F4/80 antibody has been used in immunohistochemistry.

Biochem/physiol Actions

In liquid bone marrow cultures, F4/80/EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) acts as a maturation marker for mononuclear phagocytes. EMR1 can be used as a target molecule in the treatment of individuals suffering from squamous cell carcinoma and eosinophilic disorders.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer
Harris KL, et al.
Oncotarget, 7(20), 28947-28960 (2016)
Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97
Lin HH, et al.
Genomics, 67(2), 188-200 (2000)
Jonghyo Hong et al.
Nutrients, 15(22) (2023-11-25)
Multiple studies have confirmed that Lactiplantibacillus plantarum has beneficial effects in respiratory diseases, including respiratory tract infections, asthma, and chronic obstructive pulmonary disease. However, the role of L. plantarum lysates in respiratory diseases is unclear. Staphylococcus aureus infects the lungs
Comparative evaluation of eosinophils in normal mucosa, dysplastic mucosa and oral squamous cell carcinoma with hematoxylin-eosin, Congo red, and EMR1 immunohistochemical staining techniques
Kargahi N, et al.
Electron Physician, 7(2), 1019-1026 (2015)
EMR1, the human homolog of F4/80, is an eosinophil-specific receptor
Hamann J, et al.
European Journal of Immunology, 37(10), 2797-2802 (2007)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service