SAB5700283

Anti-Phospho-BRAF-S445 antibody produced in rabbit

• Synonym(s): B-RAF1, B-raf, BRAF, BRAF1, NS7, RAFB1
• UNSPSC Code: 12352203
• NACRES: NA.43

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 84
• species reactivity: human, rat
• concentration: 2.22 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P15056
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer445)
• Gene Information: human ... BRAF(673)

Description

General description

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Immunogen

A synthetic phosphorylated peptide around S445 of human BRAF (NP_004324.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable