Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

SMB01064

Sigma-Aldrich

Dimethylfraxetin

≥90% (LC/MS-ELSD)

Synonym(s):

6,7,8,-trimethoxycoumarin, 6,7,8-trimethoxychromen-2-one, Fraxidin Methyl Ether

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C12H12O5
CAS Number:
Molecular Weight:
236.22
MDL number:
UNSPSC Code:
12352205
NACRES:
NA.25

biological source

plant

assay

≥90% (LC/MS-ELSD)

form

solid

mol wt

236.22

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

InChI

1S/C12H12O5/c1-14-8-6-7-4-5-9(13)17-10(7)12(16-3)11(8)15-2/h4-6H,1-3H3

InChI key

RAYQKHLZHPFYEJ-UHFFFAOYSA-N

General description

Dimethylfraxetin, also known as 6,7,8-Trimethoxycoumarin, a coumarin derivative, is a natural product commonly found in Pittosporum illicioides, Garcinia multiflora, and Cryptocarya bracteolata. It exhibits a range of biological activities, including anti-inflammatory, antioxidant, anticancer, and antimicrobial properties.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical and biochemical research.

Biochem/physiol Actions

  • Binds to the CB2 receptor and induces immunomodulatory effects.
  • Exhibits anti-inflammatory properties by inhibiting prostaglandin synthesis in the human erythroleukemia cell line K562.
  • Inhibits the replication of both DNA and RNA.
  • Blocks aminoacyl-tRNA binding to ribosomes, inhibiting protein synthesis.
  • Binds to phenolic acid receptors on cultured cells.

Features and Benefits

  • High quality compound suitable for multiple research applications
  • Compatible with HPLC and mass spectrometry techniques

Other Notes

For additional information on our range of Biochemicals, please complete this form.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service