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SML0059

Sigma-Aldrich

BLT-1

≥98% (HPLC)

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Synonym(s):
2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20, BLT1, Block lipid transport-1, MIT 9952-53
Empirical Formula (Hill Notation):
C12H23N3S
CAS Number:
Molecular Weight:
241.40
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥13 mg/mL

storage temp.

2-8°C

SMILES string

CCCCCCC1CCC\C1=N/NC(N)=S

InChI

1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+

InChI key

OWGUSBISUVLUJF-SDNWHVSQSA-N

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This Item
373210SML0512SML0186
vibrant-m

SML0059

BLT-1

vibrant-m

SML0512

BLT-4

vibrant-m

SML0186

Dp44mT

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

powder

form

solid

form

powder

form

powder

color

white to tan

color

white

color

white to beige

color

yellow to orange

solubility

DMSO: ≥13 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 15 mg/mL (clear solution)

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

Application

BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1.
BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux.

Biochem/physiol Actions

Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes
Maddaloni E, et al.
Cardiovascular Diabetology, 16(1), 1-11 (2017)
Ivana Halova et al.
Frontiers in immunology, 3, 119-119 (2012-06-02)
Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and react
Ceren Emre et al.
Brain pathology (Zurich, Switzerland), 30(3), 614-640 (2020-01-09)
Neuroinflammation is a key element of AD pathology and conceivably a result of a disturbed resolution. Resolution of inflammation is an active process which is strictly orchestrated following the acute inflammatory response after removal of the inflammatory stimuli. Acute inflammation
Claudia S Bitencourt et al.
Journal of cellular and molecular medicine, 17(12), 1554-1565 (2014-01-01)
Insufficient oxygen delivery to organs leads to tissue dysfunction and cell death. Reperfusion, although vital to organ survival, initiates an inflammatory response that may both aggravate local tissue injury and elicit remote organ damage. Polymorphonuclear neutrophil (PMN) trafficking to remote
Fumiyuki Sasaki et al.
PloS one, 12(9), e0185133-e0185133 (2017-09-19)
Leukotriene B4 (LTB4) receptor 1 (BLT1) is a G protein-coupled receptor expressed in various leukocyte subsets; however, the precise expression of mouse BLT1 (mBLT1) has not been reported because a mBLT1 monoclonal antibody (mAb) has not been available. In this

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