SML0180
Aceclidine hydrochloride
≥98% (HPLC)
Synonym(s):
1-Azabicyclo[2.2.2]oct-3-yl acetate hydrochloride, 3-Acetoxyquinuclidine hydrochloride
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Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥15 mg/mL at ~60 °C
storage temp.
−20°C
SMILES string
Cl.CC(=O)O[C@H]1CN2CC[C@H]1CC2
InChI
1S/C9H15NO2.ClH/c1-7(11)12-9-6-10-4-2-8(9)3-5-10;/h8-9H,2-6H2,1H3;1H/t9-;/m0./s1
InChI key
LWWSARSTZGNKGV-FVGYRXGTSA-N
Application
Aceclidine hydrochloride may be used in muscarinic acetylcholine receptor-mediated cell signaling studies.
Biochem/physiol Actions
Aceclidine hydrochloride is a parasympathomimetic drug with weak anticholinesterase activity. It acts on cholinergic nerve-endings, lowers intraocular pressure and potent therapeutic agent for open-angle glaucoma.
Aceclidine is a non-selective muscarinic acetylcholine receptor partial agonist that is effective in reducing intraocular pressure.
Muscarinic receptor partial agonist
Aceclidine at a concentration of 5 and 50 μg is capable of enhancing the outflow facility, following ciliary muscle disinsertion.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
Aceclidine effects on outflow facility after ciliary muscle disinsertion
Hubbard WC, et al.
Ophthalmologica, 210(5), 303-307 (1996)
Double-blind cross-over comparison of aceclidine and pilocarpine in open-angle glaucoma.
J H Romano
The British journal of ophthalmology, 54(8), 510-521 (1970-08-01)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML0180-10MG | 04061832075082 |
| SML0180-50MG | 04061832075099 |