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SML0309

Sigma-Aldrich

Sodium phenylbutyrate

≥98% (HPLC)

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Synonym(s):
4-PBA, 4-Phenylbutyric acid, 4-phenylbutyrate, Buphenyl, Sodium 4-phenylbutyrate, TriButyrate
Empirical Formula (Hill Notation):
C10H11NaO2
CAS Number:
Molecular Weight:
186.18
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: ≥5 mg/mL

storage temp.

room temp

SMILES string

[Na+].[O-]C(=O)CCCc1ccccc1

InChI

1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1

InChI key

VPZRWNZGLKXFOE-UHFFFAOYSA-M

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This Item
PHR32371614512Y0000808
Sodium phenylbutyrate ≥98% (HPLC)

SML0309

Sodium phenylbutyrate

Sodium Phenylbutyrate pharmaceutical secondary standard, certified reference material

PHR3237

Sodium Phenylbutyrate

Sodium phenylbutyrate United States Pharmacopeia (USP) Reference Standard

1614512

Sodium phenylbutyrate

Sodium phenylbutyrate European Pharmacopoeia (EP) Reference Standard

Y0000808

Sodium phenylbutyrate

form

powder

form

-

form

-

form

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: ≥5 mg/mL

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

General description

Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.

Application

Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Biochem/physiol Actions

Sodium phenylbutyrate is a histone deacetylase inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies
Lee YH, et al.
Scientific Reports, 6(3), 24013-24013 (2016)
Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
Lee B, et al.
Molecular Genetics and Metabolism, 100(3), 221-228 (2010)
Advances in Clinical Chemistry, Volume 17 (2014)
The Molecular and Genetic Basis of Neurologic and Psychiatric Disease (2008)
Xiujing Dou et al.
Food & nutrition research, 62 (2018-12-24)
Host defense peptides (HDPs) possess direct antibacterial, antineoplastic, and immunomodulatory abilities, playing a vital role in innate immunity. Dietary-regulated HDP holds immense potential as a novel pathway for preventing infection. In this study, we examined the regulation mechanism of HDPs

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