SML0492

Zanamivir

≥98% (HPLC)

• Synonym(s): 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid, 4-Guanidino-Neu5Ac2en
• Empirical Formula (Hill Notation): C₁₂H₂₀N₄O₇
• CAS Number: 139110-80-8
• Molecular Weight: 332.31
• MDL number: MFCD00866966
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825442
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +30 to +40°, c = 1 in H₂O
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: room temp
• SMILES string: CC(=O)N[C@@H]1[C@@H](NC(N)=N)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O
• InChI: 1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
• InChI key: ARAIBEBZBOPLMB-UFGQHTETSA-N

Description

Application

Zanamivir has been used:

• as a neuraminidase inhibitor to study its effects on influenza A virus (IAV) like particles
• as a neuraminidase inhibitor to study its effects on lipopolysaccharide (LPS)-mediated pathology in sepsis
• as an antiviral to study its effects on influenza B virus by plaque reduction assay

Biochem/physiol Actions

Zanamivir exhibits therapeutic effects against influenza caused by influenza virus A and B.

Zanamivir is an influenza viral neuraminidase inhibitor.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable