MilliporeSigma
All Photos(1)

SML0837

Sigma-Aldrich

FAK Inhibitor 14

≥95% (HPLC)

Sign Into View Organizational & Contract Pricing

Select a Size

Synonym(s):
1,2,4,5-Benzene tetraamine tetrahydrochloride, 1,2,4,5-Benzenetetraamine 4HCl, 1,2,4,5-Benzenetetraamine tetrahydrochloride, Benzene-1,2,4,5-tetramine tetrahydrochloride, NSC 667249, Y15
Empirical Formula (Hill Notation):
C6H10N4 · 4HCl
CAS Number:
Molecular Weight:
284.01
EC Number:
NACRES:
NA.77

Assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

, faint purple to dark brown

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

InChI

1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H

Inchi Key

BZDGCIJWPWHAOF-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
85610D5905S2876
FAK Inhibitor 14 ≥95% (HPLC)

Sigma-Aldrich

SML0837

FAK Inhibitor 14

form

powder

form

powder or crystals

form

tablet

form

powder or crystals

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

, faint purple to dark brown

color

-

color

-

color

-

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 0.1 g/mL, clear

solubility

water: 1 tablet/15 mL (may contain small insoluble particles)

solubility

water, high purity: 100 mg/ml

storage temp.

room temp

storage temp.

room temp

storage temp.

−20°C

storage temp.

room temp

Application

FAK Inhibitor 14 has been used in the metastasis assay. It is also used to study its effect on bone morphogenetic protein 7 (BMP-7)-induced cell crawling and adhesion.

Biochem/physiol Actions

1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival, cell proliferation and motility. Phosphorylation of FAK tyrosine 397 (Y397) forms a high affinity binding site for the SH2 domain of the Src family kinases and PI3 kinase. FAK is overexpressed in a number of human tumors. 1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14, Y15) blocks phosphorylation of Y397-FAK, which results in neuroblastoma cell detachment and apoptosis.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 8

1 of 8

PP2 ≥98% (HPLC)

Sigma-Aldrich

P0042

PP2

Sigma-Aldrich

Sigma-Aldrich

SML0612

Perifosine

Sigma-Aldrich

Sigma-Aldrich

557450

Ruthenium Red

Hydroxy-Dynasore ≥98% (HPLC)

Sigma-Aldrich

SML0340

Hydroxy-Dynasore

Erna-Zulaikha Dayang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 133, 111073-111073 (2021-01-01)
Sepsis is a life-threatening condition often leading to multiple organ failure for which currently no pharmacological treatment is available. Endothelial cells (EC) are among the first cells to respond to pathogens and inflammatory mediators in sepsis and might be a
Xiaoling Wang et al.
International journal of molecular sciences, 22(18) (2021-09-29)
By employing an innovative biohybrid membrane, the present study aimed at elucidating the mechanistic role of the focal adhesion kinase (FAK) in epithelial morphogenesis in vitro over 4, 7, and 10 days. The consequences of siRNA-mediated FAK knockdown on epithelial
The adhesion g-Protein-coupled receptor, gPr56/aDgrg1, inhibits cell?extracellular Matrix signaling to Prevent Metastatic Melanoma growth.
Millar M W, et al.
Frontiers in Oncology, 8, 8-8 (2018)
Vita Golubovskaya et al.
Archives of toxicology, 89(7), 1095-1101 (2014-06-12)
Y15 or inhibitor 14 (1,2,4,5-benzenetetramine tetrahydrochloride) is a potent and specific inhibitor of focal adhesion kinase that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. In this preclinical study, we analyzed the pharmacokinetics of
T A Sovershaev et al.
Thrombosis research, 147, 24-31 (2016-09-27)
Bone morphogenetic protein (BMP) 7 is abundant in atherosclerotic plaques and increases monocyte pro-coagulant activity by enhancing tissue factor (TF) expression. While several members of the BMP superfamily are able to serve as chemotactic agents for monocytes, the role of

Articles

Focal Adhesion Kinase (FAK) Overview

The focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase. FAK has been implicated as a downstream signaling molecule that functions in the control of several integrin-regulated biological processes.

Related Content

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service