557450
Ruthenium Red
A blocker of transmembrane Ca2+ fluxes (IC₅₀ = 7 µM) that attenuates capsaicin-induced cation channel opening.
Synonym(s):
Ruthenium Red, Ammoniated Ruthenium Oxychloride, RR
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About This Item
Recommended Products
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
red-black
solubility
ammonia: soluble
water: soluble
shipped in
ambient
storage temp.
10-30°C
General description
A blocker of transmembrane Ca2+ fluxes (IC50 = 7 µM) that attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Inhibits K+-stimulated catecholamine secretion (IC50 = 6 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Blocker of transmembrane Ca2+ fluxes
Blocker of transmembrane Ca2+ fluxes
Product does not compete with ATP.
Reversible: no
Target IC50: 7 µM in blocking transmembrane Ca2+ fluxes; 6 µM inhibiting K+-stimulated catecholamine secretion
Warning
Toxicity: Harmful (C)
Other Notes
Merck Index 13, 8379.
Phillippe, M. and Basa, A. 1996. Biochem. Biophys. Res. Commun. 221, 656.
Buratti, R., et al. 1995. Biochem. Biophys. Res. Commun. 213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995. J. Pharmacol. Exp. Ther. 273, 940.
Gomis, A., et al. 1994. Biochem. Pharmacol. 47, 225.
Stjame, P., et al. 1994. Acta Otolaryngol. 114, 651.
Ma, J. 1993. J. Gen. Physiol.102, 1031.
Phillippe, M. and Basa, A. 1996. Biochem. Biophys. Res. Commun. 221, 656.
Buratti, R., et al. 1995. Biochem. Biophys. Res. Commun. 213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995. J. Pharmacol. Exp. Ther. 273, 940.
Gomis, A., et al. 1994. Biochem. Pharmacol. 47, 225.
Stjame, P., et al. 1994. Acta Otolaryngol. 114, 651.
Ma, J. 1993. J. Gen. Physiol.102, 1031.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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