SML1350

EPPTB

≥95% (HPLC)

• Synonym(s): N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide, RO5212773
• Empirical Formula (Hill Notation): C₂₀H₂₁F₃N₂O₂
• CAS Number: 1110781-88-8
• Molecular Weight: 378.39
• MDL number: MFCD21605509
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825806
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CCOC1=CC=CC(NC(C2=CC(C(F)(F)F)=C(N3CCCC3)C=C2)=O)=C1
• InChI: 1S/C20H21F3N2O2/c1-2-27-16-7-5-6-15(13-16)24-19(26)14-8-9-18(25-10-3-4-11-25)17(12-14)20(21,22)23/h5-9,12-13H,2-4,10-11H2,1H3,(H,24,26)
• InChI key: KLFVWQCQUXXLOU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

EPPTB is a selective antagonist of the trace amine-associated receptor 1 (TAAR1), a G protein-coupled receptor (GPCR) activated by endogenous trace amines (tyramine, tryptamine, synephrine, octopamine, β)-phenylethylamine), which are chemically similar to monoaminergic neurotransmitters (epinephrine, norepinephrine, dopamine). TAAR1 is considered a promising target for the treatment of neuropsychiatric disorders, however study of TAAR1 has hampered by the fact that selective ligands have not been available. EPPTB is the first potent and selective TAAR1 antagonist with an IC₅₀ of 28 nM at mouse TAAR1. EPPTB is less selective for rat and human with IC₅₀ values of 4539 and 7487 nM, respectively.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable