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SML1994

Sigma-Aldrich

BOP

>97% (HPLC)

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Synonym(s):
N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt
Empirical Formula (Hill Notation):
C25H28N3NaO7S
CAS Number:
Molecular Weight:
537.56
NACRES:
NA.77

Assay

>97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

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SML0246SML0091SML1051
Sigma-Aldrich

Sigma-Aldrich

SML1994

BOP

L-Dopa ethyl ester ≥98% (HPLC)

Sigma-Aldrich

SML0091

L-Dopa ethyl ester

form

powder

form

powder

form

powder

form

powder

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

-

color

white to beige

color

white to beige

color

white to tan

color

white to off-white

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

DMSO: >12 mg/mL at warmed to 60 °C

solubility

H2O: ≥12 mg/mL at warmed to 60 °C

solubility

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

Biochem/physiol Actions

BOP (N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt) is a potent and selective dual inhibitor of integrins alpha-4 beta-1 (α4β1) and alpha-9 beta-1 (α9β1) with Kd values in the picomolar range. BOP has been shown to preferentially mobilize hematopoietic stem cells (HSCs) and progenitors and to act synergistically with AMD3100.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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R Blake Pepinsky et al.
Biochemistry, 41(22), 7125-7141 (2002-05-30)
Integrins alpha9beta1 and alpha4beta1 form a distinct structural class, but while alpha4beta1 has been subjected to extensive study, alpha9beta1 remains poorly characterized. We have used the small molecule N-(benzenesulfonyl)-(L)-prolyl-(L)-O-(1-pyrrolidinylcarbonyl)tyrosine (3) to investigate the biochemical properties of alpha9beta1 and directly compare
Benjamin Cao et al.
Nature communications, 7, 11007-11007 (2016-03-16)
The inherent disadvantages of using granulocyte colony-stimulating factor (G-CSF) for hematopoietic stem cell (HSC) mobilization have driven efforts to identify alternate strategies based on single doses of small molecules. Here, we show targeting α9β1/α4β1 integrins with a single dose of

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