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SML2124

Sigma-Aldrich

Ned-K

≥98% (HPLC)

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Synonym(s):
(1R,3S)-1-(3-((4-(2-Cyanophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Empirical Formula (Hill Notation):
C31H31N5O3
Molecular Weight:
521.61
MDL number:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

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This Item
SML2830SML2781SML1932
Ned-K ≥98% (HPLC)

SML2124

Ned-K

trans-Ned-19 ≥98% (HPLC)

SML2830

trans-Ned-19

NV-5440 ≥98% (HPLC)

SML2781

NV-5440

A-1210477 ≥98% (HPLC)

SML1932

A-1210477

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

Ned-K is a specific and potent inhibitor of NAADP (nicotinic acid adenine dinucleotide phosphate) signaling that suppresses Ca2+ oscillations via two-pore channels (TPC1) and opening of the mitochondrial permeability transition pore (mPTP) in cardiomyocytes during simulated ischaemia and reperfusion. Ned-K protected cardiomyocytes from cell death during ischaemia and reperfusion injury in rats.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Sean M Davidson et al.
Cardiovascular research, 108(3), 357-366 (2015-09-24)
In the heart, a period of ischaemia followed by reperfusion evokes powerful cytosolic Ca(2+) oscillations that can cause lethal cell injury. These signals represent attractive cardioprotective targets, but the underlying mechanisms of genesis are ill-defined. Here, we investigated the role

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