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Key Documents

SML2127

Sigma-Aldrich

Dynapyrazole-A

≥98% (HPLC)

Synonym(s):

2-[1-(4-Chloro-phenyl)-cyclopropyl]-7-iodo-5-oxo-4,5-dihydro-pyrazolo[1,5-a]quinazoline-3-carbonitrile

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About This Item

Empirical Formula (Hill Notation):
C20H12ClIN4O
CAS Number:
Molecular Weight:
486.69
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

IC1=CC=C(N2C(NC3=O)=C(C#N)C(C4(CC4)C5=CC=C(Cl)C=C5)=N2)C3=C1

Biochem/physiol Actions

Dynapyrazole-A is a potent dynein inhibitor. Dynapyrazole-A inhibits microtubule activity without inhibiting basal ATPase activity.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jonathan B Steinman et al.
eLife, 6 (2017-05-20)
Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has in
Alexander S Zhovmer et al.
Science advances, 10(1), eadi1788-eadi1788 (2024-01-04)
The all-terrain motility of lymphocytes in tissues and tissue-like gels is best described as amoeboid motility. For amoeboid motility, lymphocytes do not require specific biochemical or structural modifications to the surrounding extracellular matrix. Instead, they rely on changing shape and
Alexander S Zhovmer et al.
ACS nano, 15(11), 17528-17548 (2021-10-23)
Microtubules (MTs) and MT motor proteins form active 3D networks made of unstretchable cables with rod-like bending mechanics that provide cells with a dynamically changing structural scaffold. In this study, we report an antagonistic mechanical balance within the dynein-kinesin microtubular

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