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SML3564

Sigma-Aldrich

ML382

≥98% (HPLC)

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Synonym(s):
VU0485891, 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide
Empirical Formula (Hill Notation):
C18H20N2O4S
CAS Number:
Molecular Weight:
360.43
MDL number:

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=C(C=CC=C1)NS(C2CC2)(=O)=O)NC3=C(C=CC=C3)OCC

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This Item
SML1920SML3261SML1639
ML382 ≥98% (HPLC)

SML3564

ML382

Sigma-Aldrich

SML1920

ML364

JS6 ≥98% (HPLC)

SML3261

JS6

BRD3308 ≥98% (HPLC)

SML1639

BRD3308

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1
ChemMedChem, 10, 57-61 (2015)

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