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SRP6090

Sigma-Aldrich

AKR1B10 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

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Synonym(s):
AKR1B11, ALDRLn, ARL-1, Aldo-keto reductase family member B10, HIS
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

liquid

mol wt

36 kDa

packaging

pkg of 100 μg

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... AKR1B10(57016)

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This Item
SRP6371WH0057016M1SAB1405200
AKR1B10 human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

SRP6090

AKR1B10 human

Aldose Reductase human recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

SRP6371

Aldose Reductase human

assay

≥90% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

-

assay

-

biological source

human

biological source

human

biological source

mouse

biological source

mouse

form

liquid

form

liquid

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

36 kDa

mol wt

35.8 kDa (316 aa, 1-316 aa)

mol wt

-

mol wt

antigen ~33.59 kDa

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

AKR1B10 is a monomeric protein that efficiently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is ubiquitously expressed in many human tissues but is highly expressed in small intestine, colon and adrenal gland. This protein is pathogenically involved in diabetic complications. It has been reported that AKR1B10 is overexpressed in human tumors, such as liver, breast, and lung cancer, and may play a critical role in the development and progression of cancer.

Physical form

1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Yihao Tian et al.
PloS one, 6(2), e17017-e17017 (2011-03-03)
Oncogenes and tumor suppressors work in concert to regulate cell growth or death, which is a pair of antagonist factors for regulation of tumorigenesis. Here we show promoter characteristic of tumor suppressor RASSF1A, which revealed a p53 binding site in

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