General description
Apolipoprotein B is the dominant protein constituent of low-density lipoprotein (LDL). The concentration of Apo B in normal plasma is 90mg/100mL. Two forms of Apo B exist: Apo B-100 and Apo B-48. The first is found in VLDL and LDL and is produced by the liver. The second is found in chylomicrons and originates in the intestine. The gene encoding this protein is localized on chromosome 2p24.1.
Biochem/physiol Actions
Apo B is thought to stabilize lipid emulsions, serve as a cofactor and modulator of enzymatic reactions, manage export of lipids out of cells and direct lipids to target organs. Apo B levels are positively correlated with the risk of coronary disease. Apo B levels may be a more sensitive predictor of cardiovascular risk than LDL levels and do not involve fasting for accurate measurement. Mutations in this gene or its regulatory region cause hypoβ-lipoproteinemia, normotriglyceridemic and hypercholesterolemia due to ligand-defective ApoB, diseases affecting plasma cholesterol and ApoB levels.
Physical form
Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCI.
Reconstitution
In water or aqueous buffer
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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