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T3001

Sigma-Aldrich

(+)-α-Tocopherol acetate

oil or semi-solid, ~1360 IU/g

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Synonym(s):
Vitamin E acetate
Empirical Formula (Hill Notation):
C31H52O3
CAS Number:
Molecular Weight:
472.74
EC Number:
MDL number:
eCl@ss:
34058007
PubChem Substance ID:
NACRES:
NA.79

biological source

plant

Quality Level

description

Synthesized from natural α-tocopherol

form

oil or semi-solid

specific activity

~1360 IU/g

color

yellow

mp

~25 °C (lit.)

storage temp.

room temp

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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1 of 4

This Item
T115729992T3126
vibrant-m

T3001

(+)-α-Tocopherol acetate

vibrant-m

T1157

(+)-α-Tocopherol acetate

vibrant-m

29992

DL-α-Tocopherol acetate

vibrant-m

T3126

D-α-Tocopherol succinate

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

yellow

color

white to yellow

color

-

color

white to yellow

form

oil or semi-solid

form

liquid (or semi-solid)

form

liquid

form

powder

mp

~25 °C (lit.)

mp

-

mp

-

mp

-

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

General description

α-Tocopherol acetate is a fat soluble vitamin and a form of vitamin E. It can be obtained through dietary sources. RRRα-Tocopherol is a natural form of α-tocopherol.

Application

(+)-α-Tocopherol acetate has been used:
  • as a component of growth medium for retinal cell lines
  • as an external standard in high performance liquid chromatography (HPLC) to study its composition in leafy vegetables
  • in the preparation of trans-resveratrol-encapsulated lipid nanocarriers (R-nano)

Biochem/physiol Actions

α-Tocopherol is also known as a radical-chain breaker due to its anti-oxidant property.
Tocopherols (TCP) (vitamin E) are a series (α, β,γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Tocopherol acetate has properties similar but not identical to α-tocopherol.

Caution

Does not air oxidize.

hcodes

Hazard Classifications

Aquatic Chronic 4

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

ppe

Eyeshields, Gloves


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Effects of natural (RRR α-tocopherol acetate) or synthetic (all-rac α-tocopherol acetate) vitamin E supplementation on reproductive efficiency in beef cows.
Horn M, Gunn P, Van Emon M, et al.
Journal of Animal Science, 88, 3121-3127 (2011)
Partial nutrient characterization of arugula (rocket-Eruca sativa L.) and the effect of heat treatment on its lipoxidase activity
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Phenobarbital (PB) is an efficacious and well-studied hepatic tumor promoting agent. Nuclear factor-κB (NF-κB) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis. We previously found that PB activates NF-κB and that dietary
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Colloids and Surfaces. B, Biointerfaces, 164, 414-423 (2018)

Articles

Importance and uses of vitamin E (tocopherol) in serum-free eukaryotic, including hybridoma and chinese hamster ovary (CHO), cell cultures.

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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