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T3396

Sigma-Aldrich

Tetraglycol

BioXtra

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Synonym(s):
Glycofurol, Tetrahydrofurfuryl alcohol polyethyleneglycol ether
CAS Number:
31692-85-0
MDL number:
MFCD00801146
NACRES:
NA.25

description

non-ionic

Quality Level

200

product line

BioXtra

form

liquid (clear)

impurities

<0.5% water (Coulometric)
<5 ppm heavy metal

color

colorless to light yellow

mp

≤ -100  °C

solubility

water: soluble 3420 g/L

density

1.09 g/mL at 25 °C (lit.)

InChI

1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2

InChI key

CTPDSKVQLSDPLC-UHFFFAOYSA-N

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This Item
487508.21092STS0001
Tetraglycol BioXtra

Sigma-Aldrich

T3396

Tetraglycol

Genapol&#174; X-080

Sigma-Aldrich

48750

Genapol® X-080

Tetrahydrofurfuryl alcohol polyethylene glycol ether for synthesis

Sigma-Aldrich

8.21092

Tetrahydrofurfuryl alcohol polyethylene glycol ether

TERGITOL&#8482; 15-S-30 Non-ionic surfactant

Sigma-Aldrich

STS0001

TERGITOL™ 15-S-30

product line

BioXtra

product line

-

product line

-

product line

-

impurities

<0.5% water (Coulometric), <5 ppm heavy metal

impurities

-

impurities

-

impurities

-

mp

≤ -100  °C

mp

-

mp

-

mp

-

solubility

water: soluble 3420 g/L

solubility

-

solubility

-

solubility

water: soluble

density

1.09 g/mL at 25 °C (lit.)

density

1.000 g/mL±0.003 g/mL at 20 °C

density

1.08 g/cm3 at 20 °C

density

1.053 g/mL at 55 °C

Application

Tetraglycol has been used:
  • to dilute DiI (1,1′-dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perchlorate) for injecting fertilized chicken eggs for DiI labeling
  • to dilute DiI (1,1′-dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perchlorate) and diO (3,3′-dioctadecyloxacarbocyanine perchlorate) for dye/virus injections
  • to dilute poly (lactide-co-glycolide) (PLGA) to prepare PLGA/F127 solution

Used as solvent to dissolve water-insoluble compounds.

Biochem/physiol Actions

Liquid glycofurol can readily transform into gel systems with excellent elasticity due to which, it can be used as a medium to dissolve water-insoluble drugs.

Features and Benefits

Efficient solubilizer for glibenclamide (GBD)

Caution

Do not confuse with tetraethylene glycol, which is also sometimes called tetraglycol.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

275.0 °F - closed cup

Flash Point(C)

135 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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25G
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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

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X F Zhang et al.
Materials science & engineering. C, Materials for biological applications, 32(6), 1654-1663 (2012-08-01)
Poly (lactide-co-glycolide) (PLGA) - Pluronic F127 - glass composites have demonstrated excellent potential, from the perspective of controlled mechanical properties and cytocompatibility, for peripheral nerve regeneration. In addition to controlling the mechanical properties and cytotoxicity for such composite devices, the
Nahla Salah Barakat
AAPS PharmSciTech, 11(3), 1138-1146 (2010-07-24)
In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect in the topical penetration of Naproxen (NAP) was investigated. The aims of this study were to develop a suitable gel with bioadhesive property
Saly Galal et al.
Acta pharmaceutica (Zagreb, Croatia), 53(1), 57-64 (2004-02-11)
The ability of liquid and semi-solid matrix (SSM) filling capsule technology to improve the dissolution rate of glibenclamide (GBD) was investigated. Semiquantitative estimation of GBD solubility in various vehicles was carried out. Tetraglycol was found to be the most efficient
S Kehoe et al.
Journal of the mechanical behavior of biomedical materials, 14, 180-185 (2012-10-03)
PLGA/pluronic F127 based nerve guidance conduits (NGCs) for peripheral nerve regeneration offer excellent potential for clinical use. To date, little emphasis has been directed towards the effect of pluronic F127 on their subsequent mechanical properties as a function of degradation

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