42966

12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)

• Synonym(s): HS 15, Macrogol (15)-hydroxystearate, Polyethylene glycol (15)-hydroxystearate, Polyoxyethylated 12-hydroxystearic acid, Solutol^® HS 15
• CAS Number: 70142-34-6
• UNSPSC Code: 12161900
• PubChem Substance ID: 329756293
• NACRES: NA.25

Properties

• description: non-ionic
• Quality Level: 100
• form: paste
• composition: free macrogoly% (27.0 - 39.0 g/100g (%))
• impurities: acetic acid (≤ 0.5 g/100g (%)); water (≤ 0.5 g/100g (%)); ≤0.05% acetic acid; ≤0.05% water; ≤1 mg/kg ethylene oxide ((ppm)); ≤1 mg/kg ethylene oxide; ≤1 mg/kg nickel ((ppm)); ≤1 mg/kg nickle; ≤10 mg/kg dioxane ((ppm)); ≤10 mg/kg dioxane; ≤10 mg/kg heavy metals; ≤620 mg/kg Diethylene glycol; ≤620 mg/kg diethylene glycol ((ppm)); ≤620 mg/kg ethylene glycol ((ppm)); ≤620 mg/kg ethylene glycol; <10 mg/kg heavy metals ((ppm))
• ign. residue: (≤ 0.3 g/100g (%))
• pH: 5.0-7.0 (1 g/10 mL in H₂O)
• mp: 25 - 30 °C (77 - 86 °F)
• acid value: ≤1.0 mg KOH/g
• hydroxyl value: 90‑110 mg KOH/g
• iodine value: ≤2.0 g I₂/100 g
• peroxide value: ≤3.0 meq/kg
• saponification value: 53‑63 mg KOH/g
• solubility: water: 200 g/L at 30 °C (86 °F)
• density: 1.048 g/cm³ at 20 °C (68 °F); 1.03 g/cm³ at 60 °C (140 °F)
• anion traces: <1 ppm (Ethylene Oxide); <10 ppm (Dioxane)
• cation traces: Ni: <1 ppm; heavy metals: <10 ppm
• application(s): sample preservation
• SMILES string: C(CCCCC(CCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O)CCCCC(=O)O
• InChI: 1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)
• InChI key: CYAMZYIUAHNTBO-UHFFFAOYSA-N

Description

General description

12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl), a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).

Application

• 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) has been used:
• in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force
• in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses
• to dissolve finerenone for oral application in in vivo-studies

Biochem/physiol Actions

12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is mainly used as a solubilizer in parenteral and oral formulations. It is preferred for in vitro screening and in vivo efficacy studies of compounds. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is also used in ophthalmic, macromolecule, suppository, and protein formulations due to its solubilization characteristics and safety profiles. It can form micelles typically ranging from 10-15 nm. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) can be used to develop micro-emulsion IV formulations.

Other Notes

12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is a non-ionic detergent obtained by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid.

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Legal Information

Solutol is a registered trademark of BASF SE

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P280
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 521.6 °F
• flash_point_c: 272 °C