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K4894

Sigma-Aldrich

Kolliphor® P 188

solid

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Synonym(s):
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol® F68, Poloxamer 188
CAS Number:
9003-11-6
MDL number:
MFCD00082049
NACRES:
NA.75

Agency

USP/NF
meets USP testing specifications

Quality Level

200

form

solid

mol wt

8.400 g/mol

pH

5.0-7.5(2.5% solution)

application(s)

sample preservation

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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1 of 4

This Item
157597897350246
Kolliphor® P 188 solid

Sigma-Aldrich

K4894

Kolliphor® P 188

Kolliphor® P 188

Sigma-Aldrich

15759

Kolliphor® P 188

Kolliphor® P 188 micro

Sigma-Aldrich

78973

Kolliphor® P 188 micro

Kolliphor® P 407 micro

Sigma-Aldrich

50246

Kolliphor® P 407 micro

mol wt

8.400 g/mol

mol wt

~7680-9510 g/mol

mol wt

~7680-9510 g/mol

mol wt

~9840-14600 g/mol

application(s)

sample preservation

application(s)

-

application(s)

-

application(s)

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

agency

USP/NF

agency

-

agency

-

agency

-

pH

5.0-7.5(2.5% solution)

pH

5.0-7.5 (100 g/L in H2O), 6.0-7.5 (25 g/L in H2O)

pH

5.0-7.5 (2.5% in H2O)

pH

5.0-7.5(1:10), 5.0-7.5(1:40)

General description

Kolliphor® P 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.

Application

Kolliphor® P 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.
Kolliphor® P 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells. It has also been used as a component of flow cytometry (FACS) buffer as a non-ionic detergent that protects cells from hydrodynamic damage.

Biochem/physiol Actions

Kolliphor® P 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2.

Legal Information

Kolliphor is a registered trademark of BASF
Lutrol is a registered trademark of BASF SE

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

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S Dhara et al.
Nature communications, 12(1), 3044-3044 (2021-05-26)
Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
Antibody humanization by molecular dynamics simulations?in-silico guided selection of critical backmutations
Christian Margretter
Journal of Molecular Recognition (2016)
S Dhara et al.
Nature communications, 12(1), 3044-3044 (2021-05-26)
Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
Denise Chroscinski
eLife (2015)
Martin Emanuele et al.
Drugs in R&D, 14(2), 73-83 (2014-04-12)
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective properties. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis.
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