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P5556

Sigma-Aldrich

Poloxamer 188 solution

10%, sterile-filtered, BioReagent, suitable for insect cell culture

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Synonym(s):
Nonionic copolymer surfactant
CAS Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.75

description

non-ionic

Quality Level

sterility

sterile-filtered

product line

BioReagent

mol wt

average mol wt 8350

concentration

10%

technique(s)

cell culture | insect: suitable

impurities

endotoxin, tested

CMC

0.04 mM

transition temp

cloud point ≥100

HLB

29

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Sigma-Aldrich

Sigma-Aldrich

P5556

Poloxamer 188 solution

Pluronic® F-127 powder, BioReagent, suitable for cell culture

Sigma-Aldrich

P2443

Pluronic® F-127

Kolliphor® P 188 solid

Sigma-Aldrich

K4894

Kolliphor® P 188

Poloxamer 188 PRO solid, suitable for cell culture

Sigma-Aldrich

P4894

Poloxamer 188 PRO

product line

BioReagent

product line

BioReagent

product line

-

product line

-

mol wt

average mol wt 8350

mol wt

~12600 g/mol

mol wt

8.400 g/mol

mol wt

-

technique(s)

cell culture | insect: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

impurities

-

impurities

-

impurities

≤10 EU/g Endotoxin

CMC

0.04 mM

CMC

950-1000 ppm (~25°C)

CMC

-

CMC

-

General description

Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer. It comprises a central chain of hydrophobic polyoxypropylene flanked at ends by hydrophilic polyoxyethylene.

Application

A nonionic copolymer surfactant

Biochem/physiol Actions

Poloxamer 188 (P188) elicits hemorheological, antithrombotic, anti-inflammatory, and cytoprotective activities. It restores and stabilizes membrane barrier function. P188 also inhibits lipid peroxidation, reduces surface tension and hydrophobic-based cellular adherence. P-188 exhibits low toxicity and may be used in oral drug delivery.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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