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P5556

Sigma-Aldrich

Poloxamer 188 solution

10%, sterile-filtered, BioReagent, suitable for insect cell culture

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Synonym(s):
Nonionic copolymer surfactant
CAS Number:
9003-11-6
MDL number:
MFCD00082049
PubChem Substance ID:
24898666
NACRES:
NA.75

description

non-ionic

Quality Level

400
500

sterility

sterile-filtered

product line

BioReagent

mol wt

average mol wt 8350

concentration

10%

technique(s)

cell culture | insect: suitable

impurities

endotoxin, tested

CMC

0.04 mM

transition temp

cloud point ≥100

HLB

29

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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This Item
1.3711216758P2164009
Sigma-Aldrich

Sigma-Aldrich

P5556

Poloxamer 188 solution

Poloxamer 188 EMPROVE® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., NF

SAFC

1.37112

Poloxamer 188

Poloxamer 407 purified, non-ionic

Sigma-Aldrich

16758

Poloxamer 407

Poloxamer 188 European Pharmacopoeia (EP) Reference Standard

P2164009

Poloxamer 188

product line

BioReagent

product line

EMPROVE® EXPERT

product line

-

product line

-

mol wt

average mol wt 8350

mol wt

-

mol wt

-

mol wt

-

technique(s)

cell culture | insect: suitable

technique(s)

API processing | nano-milling: suitable

technique(s)

-

technique(s)

-

impurities

endotoxin, tested

impurities

-

impurities

≤1.0% water

impurities

-

CMC

0.04 mM

CMC

-

CMC

-

CMC

-

General description

Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer. It comprises a central chain of hydrophobic polyoxypropylene flanked at ends by hydrophilic polyoxyethylene.

Application

A nonionic copolymer surfactant

Biochem/physiol Actions

Poloxamer 188 (P188) elicits hemorheological, antithrombotic, anti-inflammatory, and cytoprotective activities. It restores and stabilizes membrane barrier function. P188 also inhibits lipid peroxidation, reduces surface tension and hydrophobic-based cellular adherence. P-188 exhibits low toxicity and may be used in oral drug delivery.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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