MilliporeSigma
All Photos(3)

1.37112

SAFC

Poloxamer 188

EMPROVE® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., NF

All Photos(3)
Synonym(s):
Polyethylene glycol, propoxylated
Linear Formula:
(C3H6O · C2H4O)x
CAS Number:
9003-11-6
MDL number:
MFCD00082049

Agency

NF
Ph. Eur.

Quality Level

500

product line

EMPROVE® EXPERT

form

solid

technique(s)

API processing | nano-milling: suitable

pH

5-7.5 (20 °C, 10 g/L in H2O)

mp

52 °C

transition temp

flash point 260 °C

density

1.06 g/cm3 at 70 °C

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation
solubility enhancement

storage temp.

2-25°C

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

Inchi Key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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1 of 4

This Item
P2164009P2164020P2164030
Poloxamer 188 EMPROVE® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., NF

SAFC

1.37112

Poloxamer 188

Poloxamer 188 European Pharmacopoeia (EP) Reference Standard

P2164009

Poloxamer 188

Poloxamer 237 European Pharmacopoeia (EP) Reference Standard

P2164020

Poloxamer 237

Poloxamer 407 European Pharmacopoeia (EP) Reference Standard

P2164030

Poloxamer 407

product line

EMPROVE® EXPERT

product line

-

product line

-

product line

-

form

solid

form

-

form

-

form

-

technique(s)

API processing | nano-milling: suitable

technique(s)

-

technique(s)

-

technique(s)

-

mp

52 °C

mp

-

mp

-

mp

-

transition temp

flash point 260 °C

transition temp

-

transition temp

-

transition temp

-

density

1.06 g/cm3 at 70 °C

density

-

density

-

density

-

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Poloxamer 188 is used as surfactant in a variety of liquid formulations and acts e.g. as emulsifying, solubilizing and wetting agent.
Due to its low microbial and endotoxin limits, Poloxamer 188 Emprove® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Four document types are included with an Emprove® Program subscription:

Material Qualification Dossier

Free of charge - Sign in to download

Quality Management Dossier (Open Access)

Free of charge - Sign in to download

Operational Excellence Dossier

Available by subscription or for a fee

Learn more about the benefits an Emprove® Program subscription can provide
Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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