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TRUEPVAS

Sigma-Aldrich

TrueGel3D Polymer

Modifed for slow gelling (SLO-PVA)

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shipped in

dry ice

storage temp.

−70°C

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General description

PVA polymers are functionalized with thiol-reactive groups, which react at a slower rate with thiol groups of crosslinkers (CD/PEG crosslinkers) to form stable hydrogels. The slow gelation kinetics allows enough time to conveniently manipulate the solution before the onset of homogenous gel formation. The thioglycerol is used to maintain hydrogel strength and also as a control to compare cellular behavior in peptide-modified versus unmodified hydrogels.

Application

SLO-PVA polymer is used with crosslinkers (CD/PEG crosslinkers) to establish stable hydrogels

Features and Benefits

  • Contains synthetic polymer (PVA) functionalized with thiol reactive groups for slow gelation
  • Non degradable polymer

Components

TRUEPVAS contains SLO-PVA solution in phosphate buffer, TrueGel3D thioglycerol and water

Caution

Avoid frequent freeze-thaw cycles and store SLO-PVA in small portions

pictograms

Corrosion

signalword

Warning

hcodes

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3


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Articles

The TrueGel3D™ hydrogel is formed by crosslinking RGD (arginylglycylaspartic acid) degradable polymer with CD cell-degradable crosslinker. Troubleshoot hydrogel formation and cell viability with this article.

TrueGel3D™ is a synthetic hydrogels platform for 3D cell culture that aim to mimic the natural extracellular environment for more physiological culture conditions

Protocols

An advanced protocol is available for TrueGel 3D kits for 3D cell culture for peptides concentration or stiffness optimisation

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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