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WH0007421M2

Sigma-Aldrich

Monoclonal Anti-VDR antibody produced in mouse

clone 2F4, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-NR1I1, Anti-vitamin D (1,25- dihydroxyvitamin D3) receptor
MDL number:
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2F4, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable

isotype

IgG2aκ

GenBank® accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VDR(7421)

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This Item
SAB4504326SAB4503071WH0007182M1
biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

2F4, monoclonal

clone

polyclonal

clone

polyclonal

clone

2A5, monoclonal

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

Gene Information

human ... VDR(7421)

Gene Information

human ... VDR(7421)

Gene Information

human ... VDR(7421)

Gene Information

human ... NR2C2(7182)

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General description

VDR (vitamin D receptor) or vitamin D3 receptor is a member of the steroid and thyroid hormone receptors superfamily of trans-acting transcriptional regulatory factors. It is an intracellular polypeptide of 50-60kDa. This receptor is composed of a highly conserved cysteine, lysine, and arginine-rich DNA-binding domain, and a hydrophobic ligand-binding domain in its C-terminal. It shares size and sequence similarity to thyroid hormone receptor. VDR gene is localized to human chromosome 12q12–q14.

Immunogen

VDR (AAH60832, 1 a.a. ~ 427 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS

Biochem/physiol Actions

VDR (vitamin D receptor) binds with its ligand 1a, 25-dihydroxyvitamin D3 [1,25(OH)2D3] or vitamin D3, and act upon the target cell nuclei to induce various biological effects. Vitamin D3 is also thought to have immunomodulatory effects, and gene polymorphisms are linked with pertussis. This variant might thus, affect the immune response and clinical outcome of Bordetella pertussis infection.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Cloning and expression of full-length cDNA encoding human vitamin D receptor.
Han WG
PLoS ONE (2016)
Cloning and expression of full-length cDNA encoding human vitamin D receptor.
Baker AR
Proceedings of the National Academy of Sciences of the USA (1988)
Association Between VDR FokI Polymorphism and Intervertebral Disk Degeneration.
Zhao J
Genomics, Proteomics & Bioinformatics (2015)
Isabel Heidegger et al.
Molecular cancer, 21(1), 132-132 (2022-06-19)
Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes that contribute to PCa tumor microenvironment (TME) alterations. Here we performed a detailed characterization of

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