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11022AST

Supelco

Astec® CHIROBIOTIC® V Chiral HPLC Column

5 μm particle size, L × I.D. 10 cm × 4.6 mm

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eCl@ss:
32110501
NACRES:
SB.52

material

stainless steel column

agency

suitable for USP L88

description

HPLC Column

product line

Astec®

packaging

pkg of 1 ea

manufacturer/tradename

Astec®

parameter

0-45 °C temperature
241 bar pressure (3500 psi)

technique(s)

HPLC: suitable
LC/MS: suitable

L × I.D.

10 cm × 4.6 mm

matrix

High-purity silica gel particle platform
fully porous particle

matrix active group

vancomycin phase

particle size

5 μm

pore size

100 Å

operating pH range

3.5-7.0

separation technique

chiral

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11020AST11023AST11024AST
matrix active group

vancomycin phase

matrix active group

vancomycin phase

matrix active group

vancomycin phase

matrix active group

vancomycin phase

matrix

High-purity silica gel particle platform, fully porous particle

matrix

High-purity silica gel particle platform, fully porous particle

matrix

High-purity silica gel particle platform, fully porous particle

matrix

High-purity silica gel particle platform, fully porous particle

separation technique

chiral

separation technique

chiral

separation technique

chiral

separation technique

chiral

agency

suitable for USP L88

agency

suitable for USP L88

agency

suitable for USP L88

agency

suitable for USP L88

material

stainless steel column

material

stainless steel column

material

stainless steel column

material

stainless steel column

General description

Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.

  • Bonded phase: Vancomycin
  • Operating pH range: 3.5 - 7.0
  • Particle diameter: 5, 10 or 16 μm
  • Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)

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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

Certificates of Analysis (COA)

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Chiral stability-indicating HPLC method for analysis of arotinolol in pharmaceutical formulation and human plasma
Sultan, Maha A., et al.
Arabian Journal of Chemistry, 3 (3), 147-153 (2010)
Hisham Hashem et al.
Journal of chromatography. A, 1218(38), 6727-6731 (2011-08-23)
In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the
Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series
Rao, R. Nageswara, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (21), 1911-1916 (2011)
Ana R Ribeiro et al.
Chemosphere, 95, 589-596 (2013-11-05)
Microbial degradation is the most important process to remove organic pollutants in Waste Water Treatment Plants. Regarding chiral compounds this process is normally enantioselective and needs the suitable analytical methodology to follow the removal of both enantiomers in an accurate
J P Bagnall et al.
Journal of chromatography. A, 1249, 115-129 (2012-07-04)
This paper presents and compares for the first time two chiral LC-QTOF-MS methodologies (utilising CBH and Chirobiotic V columns with cellobiohydrolase and vancomycin as chiral selectors) for the quantification of amphetamine, methamphetamine, MDA (methylenedioxyamphetamine), MDMA (methylenedioxymethamphetamine), propranolol, atenolol, metoprolol, fluoxetine

Protocols

This study demonstrates the analysis of Warfarin in plasma samples utilizing chiral and achiral (reversed-phase) LC-MS and effective sample prep to remove endogenous phospholipids

Chromatograms

suitable for GCapplication for HPLC

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