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1269105

USP

Exenatide

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
Exendin-4
Empirical Formula (Hill Notation):
C184H282N50O60S
CAS Number:
Molecular Weight:
4186.57
MDL number:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

exenatide

manufacturer/tradename

USP

application(s)

pharmaceutical

format

neat

InChI

1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1

InChI key

HTQBXNHDCUEHJF-XWLPCZSASA-N

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126899812690451269009
USP

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1269105

Exenatide

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1268998

[Glu13]-Exenatide

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1269045

[N-Acetyl-His1]-Exenatide

USP

USP

1269009

[Met(O)14]-Exenatide

manufacturer/tradename

USP

manufacturer/tradename

USP

manufacturer/tradename

USP

manufacturer/tradename

USP

application(s)

pharmaceutical

application(s)

pharmaceutical

application(s)

pharmaceutical

application(s)

pharmaceutical

format

neat

format

neat

format

neat

format

neat

API family

exenatide

API family

exenatide

API family

exenatide

API family

exenatide

Amino Acid Sequence

His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

General description

Exenatide is a 39 amino acid synthetic peptide agonist for glucagon-like peptide-1 (GLP-1) receptor. Exenatide contains NLT 95% and NMT 105% of exenatide (C184H282N50O60S), calculated on the anhydrous, acetic acid-free basis. Exenatide USP This product is a Reference Standard active pharmaceutical ingredient (API), is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Exenatide USP reference standard is used to prepare standard solutions and system suitability solutions for the identification and analysis of exenatide. Further information is available in monograph, Exenatide, USP43-NF38 – 1800 of United States Pharmacopeia (USP).

Other Notes

This product is intended for use as a reference standard in pharmaceutical research and development. This product is for test and assay use only. It is not tested for animal or human consumption, clinical testing, or therapeutic use.
Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Exenatide
USP43-NF38: United States Pharmacopeia and National Formular
United States Pharmacopeia, 45(3), 1800-1800 (2017)

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