1466696
USP
N-Nitrosomethylaminobutyric Acid (NMBA)
United States Pharmacopeia (USP) Reference Standard
Synonym(s):
4-[Methyl(nitroso)amino]butanoic acid
About This Item
Recommended Products
packaging
pkg of 1 mg
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecules)
format
neat
storage temp.
−20°C
SMILES string
N(N=O)(CCCC(=O)O)C
InChI
1S/C5H10N2O3/c1-7(6-10)4-2-3-5(8)9/h2-4H2,1H3,(H,8,9)
InChI key
SJLBIPLIGYWGJV-UHFFFAOYSA-N
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General description
Application
It is also used to prepare standard, nitrosamine standards stock solution mixture, and sensitivity solutions to determine NMBA impurity in drug substances and drug products (valsartan, irbesartan, and losartan potassium etc) by chromatography according to general chapter <1469> of United States Pharmacopeia.
Analysis Note
Other Notes
related product
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
35.6 °F
flash_point_c
2 °C
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Articles
An overview of nitrosamine impurity testing, worldwide regulations, and key considerations in filter selection for sample preparation and analysis.
This application note describes the LC-MS-based quantitative analysis of known nitrosamine impurities following procedures 1 and 3 as given in USP general chapter <1469>.
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