Genetic Screening
Screening Tools at the Scale to Meet Your Goals.
Functional genomics screens offer unique insight into the complex genetic pathways underlying drug resistance and disease but designing a screening experiment can feel daunting. With unmatched experience in lentivirus and the largest portfolio of screening products on the market, Sigma-Aldrich® Advanced Genomics will help ensure you have all the right tools to meet your research goals.
With over 350 years of technical leadership, Sigma-Aldrich® Advanced Genomics products come with expertise that extends Beyond the Bench—from discovery to therapeutic impact.
Read more about
Powerful Screening Tools for All Your Needs
Gene Knockout Screens
Gene Inhibition/Knockdown Screens
Gene Activation/Overexpression Screens
Ready-to-use Custom Lentiviral Screens
Single Cell Analysis & Deconvolution
We’re Here to Help
Powerful Screening Tools for All Your Needs
The Sigma-Aldrich® Advanced Genomics screening portfolio has been designed to provide you with a complete range of tools to enable your target discovery. Our functional genomics screens were developed with trusted partners including The Broad Institute, UCSF, The Wellcome Trust Sanger Institute and 10x Genomics.
Whether you’re looking at gene knockout, investigating loss-of-function, gain-of-function, or using a combination of gene perturbation methods, our superior range of functional genomics and gene modulation screens can be used for even the most difficult targets.
Gene Inhibition/Knockdown Screens
The MISSION® shRNA Library includes comprises the TRC1, and exclusive TRC1.5 and TRC2 collections to provide unparalleled gene coverage. Developed using UCSF designs, our whole genome CRISPRi libraries are also available as off-the shelf subpools and with 10x Genomics Feature Barcoding for single cell discovery:
Single Cell Analysis & Deconvolution
Identify hits from your pooled screens using our deconvolution services, or track your gene perturbations at single cell resolution using our 10x Genomics certified compatible products:
We’re Here to Help
Whether you need help designing your screening experiment, require assistance troubleshooting, or simply want to better understand how lentiviral screening can enhance your research, Sigma-Aldrich® Advanced Genomics is here to guide you. Connect with a Sigma-Aldrich® Advanced Genomics Expert.
Related Product Resources
- Ribonucleoprotein (RNP) Protocols Using Synthetic sgRNAs and Cas9 proteins
Combine guaranteed sgRNAs with our comprehensive range of CRISPR products and tools, including Cas9 and delivery reagents, for efficient genome modification with higher specificity.
- Brochure: Mission® RNAi Tools
- Safe Lentivirus Handling
Lentiviral vector systems prioritize safety features, with design precautions preventing replication. Good handling practices are essential for use.
- Protocol: CRISPRi User Manual
- Protocol: CRISPRa User Manual
- Functional Genomics Screening
Functional genomics screening principles using RNAi and CRISPR/Cas9 libraries for drug target identification.
- Next-Gen RNA Interference with MISSION® shRNA
RNAi technology advancements enable gene expression silencing through endogenous RNAi pathways, applicable across eukaryotes.
- Pooled Lentiviral shRNA Screens to Identify Essential Cancer Pathways
Presenting an article on Pooled Lentiviral shRNA Screens to Identify Essential Cancer Pathways
- Download your CRISPR Screening infographic
- Gene Editing 101 eBook
Learn how to understand, design and perform CRISPR experiments, as well as design gRNA, choose a Cas9 format, screen with CRISPR, use advanced CRISPR formats, and much more…
- Pooled Lentiviral shRNA Screens to Identify Essential Cancer Pathways
Presenting an article on Pooled Lentiviral shRNA Screens to Identify Essential Cancer Pathways
- Next-Gen RNA Interference with MISSION® shRNA
RNAi technology advancements enable gene expression silencing through endogenous RNAi pathways, applicable across eukaryotes.
- /US/en/technical-documents/technical-article/genomics/gene-expression-and-silencing/retinoic-acid-and-gene-expression
Related Videos
To continue reading please sign in or create an account.
Don't Have An Account?