Cleaning In Place

Cleaning in place products from 1 L to 17,000 L

Our tailor-made, top-quality Cleaning in Place (CIP) solutions help you save time, money, and effort. Instead of preparing your own solutions, simply order the volumes and concentrations you require from our GMP process solutions plant – then integrate them into your own processes, enabling re-use and protecting your chromatography resins and ultrafiltration devices. Key features include:  

  • Highest quality raw materials supplied globally, in volumes from 1 L to 17,000 L
  • Strict quality procedures and control at our global sites
  • Flexible filtration and sterile connectors
  • Mobius® single-use assemblies
  • Ready-to-use and custom options
  • Recyclable and returnable outer containers
  • Transport management for bulk GMP grade CIP solutions
  • Resources for proper handling of hazardous goods
  • Advanced discharge system to increase the safety of handling caustics and acids
  • Up-to-date regulatory support 

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Increase Bioburden Control and Reusability of Your Purification Steps

Every year, biopharmaceutical production facilities use vast quantities of CIP solutions to clean and store their chromatography resins and TFF cassettes. And every year, more and more companies order our tailor-made products rather than preparing them themselves. They know from experience that our top-quality, ready-for-use CIP solutions can save time and money – and allow them to work smarter.

Protect Chromatography Media and Ultrafiltration/TFF Devices

Our high-quality solutions for cleaning and storing of chromatography media such as our Fractogel® and ProSep® resins, as well as ultrafiltration Pellicon® cassettes, are designed to meet the specific demands of our customers in the biopharmaceutical industry. These products fulfill the highest requirements to purity and reliability, and they effectively prevent contamination of your valuable purification equipment.

GMP Grade CIP Solutions

All our solutions are manufactured under GMP conditions and feature low bioburden levels. Moreover, they are backed by our industry-leading Emprove® Program for exceptional quality and documentation support. To ensure the highest standards of purity and quality, we use only pharmaceutical-quality raw materials (such as sodium hydroxide), and highly purified water according to European and US pharmacopoeia (Ph Eur, USP). As a result, you can integrate our solutions directly into your own cleanroom.

Our CIP products include:

  • Citric acid
  • Sodium hydroxide solutions: 0.05 N – 50%
  • Sodium hydroxide solutions, low iron: 20/25/30%
  • Hydrochloric acid and acetic acid in different concentrations
  • Ethanol 20% (w/w)
  • Potassium hydroxide
  • Sodium hydroxide pellets (Ph Eur, USP)
  • Ethylene glycol

Simplify Approval and Validation Procedures

We also provide technical support regarding packaging and full regulatory documentation. To help you stay on top of regulatory changes and simplify your processes, our manufacturing sites have 100% access to our industry-leading Emprove® Program. This powerful, always up-to-date repository of current and anticipated regulatory data supports our high-quality pharmaceutical and biopharmaceutical raw materials and consumables, providing you with comprehensive documentation that can:

  • Speed approval preparation and extend compliance
  • Facilitate the qualification process
  • Support risk assessment
  • Increase supply chain transparency

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