MilliporeSigma

Novel pH-responsive nanoparticles.

Langmuir : the ACS journal of surfaces and colloids (2008-08-09)
Sergey Filippov, Martin Hrubý, Cestmír Konák, Hana Macková, Milena Spírková, Petr Stepánek
ABSTRACT

In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly( N-methacryloyl- l-valine) or poly( N-methacryloyl- l-phenylalanine), and nonionic surfactant (Brij 98) in the presence of hydrochloric acid. The influence of composition and pH on particles size and shape was investigated by a variety of methods. An entity's size and polydispersity could be varied in a broad range making them a perspective candidate as a drug carrier. Unlike the case of typical micelles, our results indicate the presence of cavities in the formed particles. A hypothetical model of a nanoparticle and mechanism of formation are proposed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
BRIJ® O20, average Mn ~1,150
Sigma-Aldrich
ECO BRIJ® O20, average Mn ~1,150
Sigma-Aldrich
ECO BRIJ® O10
Sigma-Aldrich
Brij® O10
Sigma-Aldrich
Brij® 93, average Mn ~357