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BRIJ® O20

average Mn ~1,150

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Synonym(s):
Polyoxyethylene (20) oleyl ether
Linear Formula:
C18H35(OCH2CH2)nOH, n~20
CAS Number:
Molecular Weight:
1149.53
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23

description

non-ionic

Quality Level

mol wt

average Mn ~1,150

technique(s)

cell culture | mammalian: suitable
protein quantification: suitable

mp

25-30 °C (lit.)

HLB

15

InChI

1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22-20-18-21/h9-10,21H,2-8,11-20H2,1H3/b10-9-

InChI key

KWVPFECTOKLOBL-KTKRTIGZSA-N

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General description

Brij® O20 is a non-ionic surfactant that has an 18 carbon tail with a single double bond and the head contains 20 ethylene oxide moieties. It is polyethoxylated fatty alcohol that is hydrophilic in nature.

Application

Brij® O20 has been used:
  • as a detergent in medium A to prepare single detergent micelle aggregates
  • along with phosphate buffer saline (PBS) solution as the receptor solution for terbinafine (TBF) for in vitro permeation studies of TBF-free base in porcine skin
  • as a detergent to isolate detergent-resistant membranes from the mouse brain and to determine the distribution of major mammalian brain gangliosides, GM1, GD1a, GD1b and GT1b

Legal Information

Brij is a registered trademark of Croda International PLC

pictograms

Exclamation markEnvironment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Chronic 2 - Skin Irrit. 2

wgk_germany

WGK 1

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


Certificates of Analysis (COA)

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Mixed Micellization of Polyoxyethylene (20) Oleyl Ether with Cetylpyridinium Chloride at the Air-Water Interface
Desai S and Bhagwat SS
Journal of Surfactants and Detergents, 19(6), 1169-1174 (2016)
Pulkit Khatri et al.
Journal of pharmaceutical sciences, 107(8), 2198-2207 (2018-04-08)
The study aims to elucidate the mechanism and the role of the molecular structure of surfactants and lipids in the formation of oil-in-water (o/w) self-emulsified nanoemulsions (SENs). The hypothesis is that the overall change of Gibb's free energy (ΔGf) during
Towards a new universal way to describe the required hydrophilic lipophilic balance of oils using the phase inversion temperature of C10E4/n-octane/water emulsions
Royer M, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 536, 165-171 (2018)
Gunasekaran Dhandapani et al.
Biotechnology and bioengineering, 119(7), 1997-2003 (2022-03-25)
Immunoglobulin M (IgM) antibodies hold promise as anticancer drugs and as agents for promoting immune homeostasis. This promise has not been realized due to low expression levels in mammalian cells producing IgM class antibodies, and the failure of protein A
Carles Gil et al.
Biochemical and biophysical research communications, 348(4), 1334-1342 (2006-08-22)
Although the high presence of cholesterol in nerve terminals is well documented, specific roles of this lipid in transmitter release have remained elusive. Since cholesterol is a highly enriched component in the membrane microdomains known as lipid rafts, it is

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