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436240

Sigma-Aldrich

BRIJ® O20

average Mn ~1,150

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Synonym(s):
Polyoxyethylene (20) oleyl ether
Linear Formula:
C18H35(OCH2CH2)nOH, n~20
CAS Number:
Molecular Weight:
1149.53
MDL number:
NACRES:
NA.23

description

non-ionic

Quality Level

mol wt

average Mn ~1,150

technique(s)

cell culture | mammalian: suitable
protein quantification: suitable

mp

25-30 °C (lit.)

HLB

15

InChI

1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-22-20-18-21/h9-10,21H,2-8,11-20H2,1H3/b10-9-

InChI key

KWVPFECTOKLOBL-KTKRTIGZSA-N

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1 of 4

This Item
388866STS0218P4019
BRIJ® O20 average Mn ~1,150

Sigma-Aldrich

436240

BRIJ® O20

Brij® 93 average Mn ~357

Sigma-Aldrich

388866

Brij® 93

ECO Brij® S20

Sigma-Aldrich

STS0218

ECO Brij® S20

Brij® S20

Sigma-Aldrich

P4019

Brij® S20

mol wt

average Mn ~1,150

mol wt

average Mn ~357

mol wt

-

mol wt

-

technique(s)

cell culture | mammalian: suitable, protein quantification: suitable

technique(s)

-

technique(s)

-

technique(s)

-

mp

25-30 °C (lit.)

mp

-

mp

44-46 °C (lit.)

mp

44-46 °C (lit.)

HLB

15

HLB

4

HLB

15.3

HLB

15

General description

Brij® O20 is a non-ionic surfactant that has an 18 carbon tail with a single double bond and the head contains 20 ethylene oxide moieties. It is polyethoxylated fatty alcohol that is hydrophilic in nature.

Application

Brij® O20 has been used:
  • as a detergent in medium A to prepare single detergent micelle aggregates
  • along with phosphate buffer saline (PBS) solution as the receptor solution for terbinafine (TBF) for in vitro permeation studies of TBF-free base in porcine skin
  • as a detergent to isolate detergent-resistant membranes from the mouse brain and to determine the distribution of major mammalian brain gangliosides, GM1, GD1a, GD1b and GT1b

Legal Information

Brij is a registered trademark of Croda International PLC

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Chronic 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

464.0 °F - Equilibrium method

Flash Point(C)

> 240 °C - Equilibrium method

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Towards a new universal way to describe the required hydrophilic lipophilic balance of oils using the phase inversion temperature of C10E4/n-octane/water emulsions
Royer M, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 536, 165-171 (2018)
Mixed Micellization of Polyoxyethylene (20) Oleyl Ether with Cetylpyridinium Chloride at the Air-Water Interface
Desai S and Bhagwat SS
Journal of Surfactants and Detergents, 19(6), 1169-1174 (2016)
Pulkit Khatri et al.
Journal of pharmaceutical sciences, 107(8), 2198-2207 (2018-04-08)
The study aims to elucidate the mechanism and the role of the molecular structure of surfactants and lipids in the formation of oil-in-water (o/w) self-emulsified nanoemulsions (SENs). The hypothesis is that the overall change of Gibb's free energy (ΔGf) during
Gunasekaran Dhandapani et al.
Biotechnology and bioengineering, 119(7), 1997-2003 (2022-03-25)
Immunoglobulin M (IgM) antibodies hold promise as anticancer drugs and as agents for promoting immune homeostasis. This promise has not been realized due to low expression levels in mammalian cells producing IgM class antibodies, and the failure of protein A
Yash Kapoor et al.
Journal of colloid and interface science, 322(2), 624-633 (2008-03-25)
Surfactants are commonly incorporated into hydrogels to increase solute loading and attenuate the release rates. In this paper we focus on understanding and modeling the mechanisms of both surfactant and drug transport in hydrogels. Specifically, we focus on Brij 98

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