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235989

Sigma-Aldrich

Brij® L4

average Mn ~362

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Synonym(s):
Polyethylene glycol dodecyl ether, Polyoxyethylene (4) lauryl ether
Linear Formula:
(C20H42O5)n
CAS Number:
9002-92-0
MDL number:
MFCD00043063
PubChem Substance ID:
24854130
NACRES:
NA.21

description

non-ionic

Quality Level

200

mol wt

average Mn ~362

refractive index

n20/D 1.451 (lit.)

density

0.95 g/mL at 25 °C (lit.)

HLB

9

SMILES string

CCCCCCCCCCCCOCCOCCOCCOCCO

InChI

1S/C20H42O5/c1-2-3-4-5-6-7-8-9-10-11-13-22-15-17-24-19-20-25-18-16-23-14-12-21/h21H,2-20H2,1H3

InChI key

WPMWEFXCIYCJSA-UHFFFAOYSA-N

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1 of 4

This Item
P1254STS021216005
Brij® L4 average Mn ~362

Sigma-Aldrich

235989

Brij® L4

Brij® L23 suitable for Stein-Moore chromatography

Sigma-Aldrich

P1254

Brij® L23

ECO BRIJ® L4 average Mn ~362

Sigma-Aldrich

STS0212

ECO BRIJ® L4

Brij® L23 main component: tricosaethylene glycol dodecyl ether

Sigma-Aldrich

16005

Brij® L23

mol wt

average Mn ~362

mol wt

micellar avg mol wt 48,000, estimated mol wt 1198

mol wt

average Mn ~362

mol wt

-

density

0.95 g/mL at 25 °C (lit.)

density

-

density

0.95 g/mL at 25 °C (lit.)

density

-

HLB

9

HLB

16.9

HLB

9.7

HLB

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

refractive index

n20/D 1.451 (lit.)

refractive index

-

refractive index

n20/D 1.451 (lit.)

refractive index

-

General description

Brij® L4 is a non-ionic surfactant. It comprises an alkyl (C12) tail attached to an oxyethylene headgroup.

Application

Brij® L4 has been used:
  • as a surfactant for the synthesis of copper(I) oxide (Cu2O) spherical nanoparticles using a microemulsion technique
  • as a non-ionic surfactant for preparing reverse micelles to synthesize Pt3Co alloy nanoparticles
  • as a surfactant to enhance the efficiency of interfacial coupling of hydrophobic materials and to make hydrogel

Biochem/physiol Actions

Brij® L4 exhibits amphiphilic properties. Brij L4 contains hydrophobic and hydrophilic regions that can form micelles and disperse hydrophobic drugs into the core of micelles. This in turn enhances drug solubility. Brij L4 also elicits a strong inhibitory effect against breast cancer resistance protein (BCRP) mediated drug efflux. It inhibits Taq adsorption better when compared to other commonly used surfactants. Brij L4 supports droplet polymerase chain reaction (PCR) in picoliter reaction volumes at standard Taq concentrations.

Legal Information

Brij is a registered trademark of Croda International PLC

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302 - H315 - H319 - H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Copper (i) oxide nanoparticle-mediated C-C couplings for synthesis of polyphenylenediethynylenes: Evidence for a homogeneous catalytic pathway
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